Proteintech

Drosha Polyclonal Antibody

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Drosha Antibody (55001-1-AP) in WB

HEK-293 cells were subjected to SDS PAGE followed by western blot with 55001-1-AP (Drosha antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

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Product Details

55001-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 6 publications 6 publications

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.21 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

The antibody is specific to DROSHA. DROSHA/RNASEN has some transcription forms with MW 160 kDa, 151 kDa, 138 kDa, and 90 kDa.

Target Information

Members of the ribonuclease III superfamily of double-stranded (ds) RNA-specific endoribonucleases participate in diverse RNA maturation and decay pathways in eukaryotic and prokaryotic cells (Fortin et al., 2002). The RNase III Drosha is the core nuclease that executes the initiation step of microRNA (miRNA) processing in the nucleus (Lee et al., 2003).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

HBV induced the discharge of intrinsic antiviral miRNAs in HBV-replicating hepatocytes via extracellular vesicles to facilitate its replication.

The Journal of general virology

Chu Q,Li J,Chen J,Yuan Z

Sun May 01 00:00:00 EDT 2022

FoxP3-miR-150-5p/3p suppresses ovarian tumorigenesis via an IGF1R/IRS1 pathway feedback loop.

Cell death & disease

Zhang Q,Zhou X,Wan M,Zeng X,Luo J,Xu Y,Ji L,Zhang JA,Fan P,Zhong J,Wu J

Mon Mar 15 00:00:00 EDT 2021

METTL3 regulates skeletal muscle specific miRNAs at both transcriptional and post-transcriptional levels.

Biochemical and biophysical research communications

Diao LT,Xie SJ,Lei H,Qiu XS,Huang MC,Tao S,Hou YR,Hu YX,Sun YJ,Zhang Q,Xiao ZD

Fri May 07 00:00:00 EDT 2021

Hydrogen sulfide rescues high glucose-induced migration dysfunction in HUVECs by upregulating miR-126-3p.

American journal of physiology. Cell physiology

Xue WL,Chen RQ,Zhang QQ,Li XH,Cao L,Li MY,Li Y,Lin G,Chen Y,Wang MJ,Zhu YC

Fri May 01 00:00:00 EDT 2020

Biological and RNA regulatory function of MOV10 in mammalian germ cells.

BMC biology

Fu K,Tian S,Tan H,Wang C,Wang H,Wang M,Wang Y,Chen Z,Wang Y,Yue Q,Xu Q,Zhang S,Li H,Xie J,Lin M,Luo M,Chen F,Ye L,Zheng K

Tue May 14 00:00:00 EDT 2019

Zinc-finger protein YY1 suppresses tumor growth of human nasopharyngeal carcinoma by inactivating c-Myc-mediated microRNA-141 transcription.

The Journal of biological chemistry

Li M,Liu Y,Wei Y,Wu C,Meng H,Niu W,Zhou Y,Wang H,Wen Q,Fan S,Li Z,Li X,Zhou J,Cao K,Xiong W,Zeng Z,Li X,Qiu Y,Li G,Zhou M

Fri Apr 12 00:00:00 EDT 2019

The Fragment HMGA2-sh-3p20 from HMGA2 mRNA 3'UTR Promotes the Growth of Hepatoma Cells by Upregulating HMGA2.

Scientific reports

Wang Y,Chen F,Yang Z,Zhao M,Zhang S,Gao Y,Feng J,Yang G,Zhang W,Ye L,Zhang X

Thu May 18 00:00:00 EDT 2017

The Fragment HMGA2-sh-3p20 from HMGA2 mRNA 3'UTR Promotes the Growth of Hepatoma Cells by Upregulating HMGA2.

Scientific reports

Wang Y,Chen F,Yang Z,Zhao M,Zhang S,Gao Y,Feng J,Yang G,Zhang W,Ye L,Zhang X

Thu May 18 00:00:00 EDT 2017

Post-transcriptional modulation of protein phosphatase PPP2CA and tumor suppressor PTEN by endogenous siRNA cleaved from hairpin within PTEN mRNA 3'UTR in human liver cells.

Acta pharmacologica Sinica

Gao YE,Wang Y,Chen FQ,Feng JY,Yang G,Feng GX,Yang Z,Ye LH,Zhang XD

Fri Jul 01 00:00:00 EDT 2016

Post-transcriptional modulation of protein phosphatase PPP2CA and tumor suppressor PTEN by endogenous siRNA cleaved from hairpin within PTEN mRNA 3'UTR in human liver cells.

Acta pharmacologica Sinica

Gao YE,Wang Y,Chen FQ,Feng JY,Yang G,Feng GX,Yang Z,Ye LH,Zhang XD

Fri Jul 01 00:00:00 EDT 2016

Bioinformatics

Protein Aliases: drosha, double-stranded RNA-specific endoribonuclease; drosha, ribonuclease type III; ethanol induced 2; MGC115770; nuclear RNase III Drosha; OTTHUMP00000220910; OTTHUMP00000220911; OTTHUMP00000220912; OTTHUMP00000220913; p241; Protein Drosha; putative protein p241 which interacts with transcription factor Sp1; putative ribonuclease III; Ribonuclease 3; Ribonuclease III; ribonuclease III, nuclear; ribonuclease type III, nuclear; RNase III

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Gene Aliases: 1110013A17Rik; AI874853; DROSHA; ETOHI2; HSA242976; RANSE3L; RGD1307626; RN3; RNASE3L; RNASEN

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UniProt ID: (Human) Q9NRR4, (Mouse) Q5HZJ0

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Entrez Gene ID: (Human) 29102, (Mouse) 14000, (Rat) 310159

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Function(s)

lipopolysaccharide binding double-stranded RNA binding ribonuclease III activity protein binding protein homodimerization activity poly(A) RNA binding metal ion binding primary miRNA binding RNA binding nuclease activity endonuclease activity endoribonuclease activity hydrolase activity molecular_function endoribonuclease

Process(es)

miRNA metabolic process positive regulation of gene expression rRNA catabolic process production of siRNA involved in RNA interference gene silencing by RNA primary miRNA processing pre-miRNA processing ribosome biogenesis defense response to Gram-negative bacterium defense response to Gram-positive bacterium RNA phosphodiester bond hydrolysis, endonucleolytic regulation of miRNA metabolic process RNA processing regulation of gene expression RNA phosphodiester bond hydrolysis biological_process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Drosha Polyclonal Antibody

Drosha Antibody (55001-1-AP) in WB

Product Details

55001-1-AP

Western Blot (WB)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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