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Product Details
BS-13033R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human Drosha/RNase III Drosha, amino acids 751-850.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Members of the ribonuclease III superfamily of double-stranded (ds) RNA-specific endoribonucleases participate in diverse RNA maturation and decay pathways in eukaryotic and prokaryotic cells (Fortin et al., 2002). The RNase III Drosha is the core nuclease that executes the initiation step of microRNA (miRNA) processing in the nucleus (Lee et al., 2003).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: drosha, double-stranded RNA-specific endoribonuclease; drosha, ribonuclease type III; ethanol induced 2; MGC115770; nuclear RNase III Drosha; OTTHUMP00000220910; OTTHUMP00000220911; OTTHUMP00000220912; OTTHUMP00000220913; p241; Protein Drosha; putative protein p241 which interacts with transcription factor Sp1; putative ribonuclease III; Ribonuclease 3; Ribonuclease III; ribonuclease III, nuclear; ribonuclease type III, nuclear; RNase III
Gene Aliases: 1110013A17Rik; AI874853; DROSHA; ETOHI2; HSA242976; RANSE3L; RGD1307626; RN3; RNASE3L; RNASEN
UniProt ID: (Human) Q9NRR4, (Mouse) Q5HZJ0
Entrez Gene ID: (Human) 29102, (Mouse) 14000, (Rat) 310159
lipopolysaccharide binding
double-stranded RNA binding
ribonuclease III activity
protein binding
protein homodimerization activity
poly(A) RNA binding
metal ion binding
primary miRNA binding
RNA binding
nuclease activity
endonuclease activity
endoribonuclease activity
hydrolase activity
molecular_function
endoribonuclease
miRNA metabolic process
positive regulation of gene expression
rRNA catabolic process
production of siRNA involved in RNA interference
gene silencing by RNA
primary miRNA processing
pre-miRNA processing
ribosome biogenesis
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
RNA phosphodiester bond hydrolysis, endonucleolytic
regulation of miRNA metabolic process
RNA processing
regulation of gene expression
RNA phosphodiester bond hydrolysis
biological_process
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