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Proteintech
Dystroglycan Monoclonal Antibody (2B1G12), CoraLite® Plus 488
Product Details
CL488-66735
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2B1G12
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Purification
Protein G
Storage buffer
PBS with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20° C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: VGEKSWVQFN SNSQLMYGLP DSSHVGKHEY FMHATDKGGL SAVDAFEIHV HRRPQGDRAP ARFKAKFVGD PALVLNDIHK KIALVKKLAF AFGDRNCSTI TLQNITRGSI VVEWTNNTLP LEPCPKEQIA GLSRRIAEDD GKPRPAFSNA LEPDFKATSI TVTGSGSCRH LQFIPVVPPR RVPSEAPPTE VPDRDPEKSS EDDVYLHTVI PAVVVAAILL IAGIIAMICY RKKRKGKLTL EDQATFIKKG VPIIFADELD DSKPPPSSSM PLILQEEKAP LPPPEYPNQS VPETTPLNQD TMGEYTPLRD EDPNAPPYQP PPPFTAPMEG KGSRPKNMTP YRSPPPYVPP
Target Information
Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha-dystroglycan; beta-dystroglycan; Dystroglycan; Dystroglycan 1; dystroglycan 1 (dystrophin-associated glycoprotein 1); dystrophin associated glycoprotein 1; Dystrophin-associated glycoprotein 1
Gene Aliases: 156DAG; A3a; AGRNR; D9Wsu13e; DAG; DAG1; DG; Dp427; Dp71; MDDGA9; MDDGC7; MDDGC9
UniProt ID: (Human) Q14118, (Mouse) Q62165
Entrez Gene ID: (Human) 1605, (Pig) 100620392, (Mouse) 13138, (Rat) 114489
morphogenesis of an epithelial sheet
protein O-linked glycosylation
membrane protein ectodomain proteolysis
NLS-bearing protein import into nucleus
cytoskeletal anchoring at plasma membrane
regulation of gastrulation
regulation of epithelial to mesenchymal transition
calcium-dependent cell-matrix adhesion
regulation of embryonic cell shape
modulation by virus of host morphology or physiology
nerve maturation
myelination in peripheral nervous system
extracellular matrix organization
negative regulation of cell migration
microtubule anchoring
negative regulation of MAPK cascade
response to peptide hormone
viral entry into host cell
negative regulation of protein kinase B signaling
epithelial tube branching involved in lung morphogenesis
branching involved in salivary gland morphogenesis
commissural neuron axon guidance
basement membrane organization
positive regulation of basement membrane assembly involved in embryonic body morphogenesis
Schwann cell development
viral process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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