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Product Details
16931-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
EAPP Fusion Protein Ag10403 (1-285 aa encoded by BC001245)
Conjugate
Form
Liquid
Concentration
0.17 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MNRLPDDYD PYAVEEPSDE EPALSSSEDE VDVLLHGTPD QKRKLIRECL TGESESSSED EFEKEMEAEL NSTMKTMEDK LSSLGTGSSS GNGKVATAPT RYYDDIYFDS DSEDEDRAVQ VTKKKKKKQH KIPTNDELLY DPEKDNRDQA WVDAQRRGYH GLGPQRSREQ QPVPNSDAVL NCPACMTTLC LDCQRHESYK TQYRAMFVMN CSINKEEVLR YKASENRKKR RVHKKMRSNQ EDAAEKAETD VEEIYHPVMC TECSTEVAVY DKDEVFHFFN VLASHS (1-285 aa encoded by B C001245)
Target Information
This protein may play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. The C-terminal of EAPP binds the N-terminal of E2F1 and also interacts with E2F2 and E2F3, but not E2F4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E2F-associated phosphoprotein; EAPP
Gene Aliases: 1810011O16Rik; BM-036; BM036; C14orf11; EAPP; RGD1309624
UniProt ID: (Human) Q56P03, (Mouse) Q5BU09
Entrez Gene ID: (Human) 55837, (Mouse) 66266, (Rat) 299043
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