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Product Details
67179-1-IG
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1D5E8
Immunogen
ECD Fusion Protein Ag28674
Conjugate
Form
Liquid
Concentration
500 µg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345). May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839). The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270). May play a role in regulation of pre-mRNA splicing (PubMed:24722212). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ecdysoneless homolog; ecdysoneless homolog (Drosophila); hSGT1; Human suppressor of GCR two; Protein ecdysoneless homolog; protein SGT1; protein SGT1 homolog; SGT1 protein; suppressor of GCR2; suppressor of S. cerevisiae gcr2
Gene Aliases: 5730461K03Rik; ECD; GCR2; HSGT1; RGD1565023; SGT1
UniProt ID: (Human) O95905, (Mouse) Q9CS74
Entrez Gene ID: (Human) 11319, (Mouse) 70601, (Rat) 688968
regulation of glycolytic process
transcription from RNA polymerase II promoter
mRNA processing
cell proliferation
RNA splicing
positive regulation of transcription from RNA polymerase II promoter
regulation of G1/S transition of mitotic cell cycle
transcription, DNA-templated
regulation of transcription, DNA-templated
Performance Guarantee
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