Proteintech

ECM1 Polyclonal Antibody

ECM1 Antibody in Immunocytochemistry (ICC/IF)

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ECM1 Antibody (11521-1-AP) in ICC/IF

Immunofluorescent analysis of ( 10% Formaldehyde ) fixed HepG2 cells using 11521-1-AP (ECM1 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

ECM1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

11521-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 9 publications 9 publications

Immunohistochemistry (IHC)

View 11 publications 11 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:400

Immunocytochemistry (ICC/IF)

1:50-1:500

View 5 publications 5 publications

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Dog, Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ECM1 Fusion Protein Ag2084 (241-540 aa encoded by BC023505)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.19 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSRFCEAEF SVKTRPHWCC TRQGEARFSC FQEEAPQPHY QLRACPSHQP DISSGLELPF PPGVPTLDNI KNICHLRRFR SVPRNLPATD PLQRELLALI QLEREFQRCC RQGNNHTCTW KAWEDTLDKY CDREYAVKTH HHLCCRHPPS PTRDECFARR APYPNYDRDI LTIDISRVTP NLMGHLCGNQ RVLTKHKHIP GLIHNMTARC CDLPFPEQAC CAEEEKLTFI NDLCGPRRNI WRDPALCCYL SPGDEQVNCF NINYLRNVAL VSGDTENAKG QGEQGSTGGT NISSTSEPKE E (241-540 aa encoded by BC023505)

Target Information

ECM1, also referred to as extracellular matrix protein 1, is a protein that plays a significant role in regulating extracellular matrix organization and cell adhesion. It is expressed in various tissues, including the skin, lung, and liver, and is involved in the development and progression of several diseases, including cancer and dermatological disorders. The protein interacts with several extracellular matrix proteins, such as collagen and fibronectin, and is involved in the regulation of cell proliferation, migration, and invasion. ECM1 is also involved in endochondral bone formation, angiogenesis, and tumor biology. It interacts with various extracellular and structural proteins, contributing to the maintenance of skin integrity and homeostasis. Mutations in this gene are associated with lipoid proteinosis disorder (also known as hyalinosis cutis et mucosae or Urbach-Wiethe disease) that is characterized by generalized thickening of skin, mucosae, and certain viscera. Different isoforms of ECM1 have been described in alternatively spliced transcript variants. Diseases associated with ECM1 include Lipoid Proteinosis Of Urbach And Wiethe and Lichen Sclerosus Et Atrophicus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

DKK3's protective role in prostate cancer is partly due to the modulation of immune-related pathways.

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Shareef ZA,Hachim MY,Talaat IM,Bhamidimarri PM,Ershaid MNA,Ilce BY,Venkatachalam T,Eltayeb A,Hamoudi R,Hachim IY

Tue Feb 28 00:00:00 EST 2023

Endometrial extracellular matrix components do not change over the course of embryonic diapause and reactivation in the roe deer (Capreolus capreolus).

Reproduction in domestic animals = Zuchthygiene

Rüegg AB,Kowalewski MP,Ulbrich SE

Mon May 01 00:00:00 EDT 2023

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Molecular omics

Yang J,Liu Q,Yu B,Han B,Yang B

Mon Jan 17 00:00:00 EST 2022

Antigestagens Mediate the Expression of Decidualization Markers, Extracellular Matrix Factors and Connexin 43 in Decidualized Dog Uterine Stromal (DUS) Cells.

Animals : an open access journal from MDPI

Kazemian A,Tavares Pereira M,Hoffmann B,Kowalewski MP

Tue Mar 22 00:00:00 EDT 2022

ECM1 modified HF-MSCs targeting HSC attenuate liver cirrhosis by inhibiting the TGF-β/Smad signaling pathway.

Cell death discovery

Liu Q,Lv C,Huang Q,Zhao L,Sun X,Ning D,Liu J,Jiang Y,Jin S

Tue Feb 08 00:00:00 EST 2022

Global proteome profiling of human livers upon ischemia/reperfusion treatment.

Clinical proteomics

Cai H,Qi S,Yan Q,Ling J,Du J,Chen L

Wed Jan 06 00:00:00 EST 2021

ROBO2 hampers malignant biological behavior and predicts a better prognosis in pancreatic adenocarcinoma.

Scandinavian journal of gastroenterology

Ding C,Li Y,Wang S,Xing C,Chen L,Zhang H,Wang Y,Dai M

Sun Aug 01 00:00:00 EDT 2021

Canine decidualization in vitro: extracellular matrix modification, progesterone mediated effects and selective blocking of prostaglandin E2 receptors.

The Journal of reproduction and development

Graubner FR,Tavares Pereira M,Boos A,Kowalewski MP

Thu Aug 20 00:00:00 EDT 2020

MiR-92a antagonized the facilitation effect of extracellular matrix protein 1 in GC metastasis through targeting its 3'UTR region.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Liu LQ,Hu L,Hu XB,Xu J,Wu AM,Chen H,Gu PY,Hu SL

Fri Nov 01 00:00:00 EDT 2019

miR-23a-5p inhibits cell proliferation and invasion in pancreatic ductal adenocarcinoma by suppressing ECM1 expression.

American journal of translational research

Huang W,Huang Y,Gu J,Zhang J,Yang J,Liu S,Xie C,Fan Y,Wang H

Tue Sep 29 00:00:00 EDT 2020

miR-23a-5p inhibits cell proliferation and invasion in pancreatic ductal adenocarcinoma by suppressing ECM1 expression.

American journal of translational research

Huang W,Huang Y,Gu J,Zhang J,Yang J,Liu S,Xie C,Fan Y,Wang H

Tue Sep 29 00:00:00 EDT 2020

Extracellular matrix protein 1 promotes cell metastasis and glucose metabolism by inducing integrin β4/FAK/SOX2/HIF-1α signaling pathway in gastric cancer.

Oncogene

Gan L,Meng J,Xu M,Liu M,Qi Y,Tan C,Wang Y,Zhang P,Weng W,Sheng W,Huang M,Wang Z

Thu Feb 08 00:00:00 EST 2018

Extracellular matrix protein 1 promotes cell metastasis and glucose metabolism by inducing integrin β4/FAK/SOX2/HIF-1α signaling pathway in gastric cancer.

Oncogene

Gan L,Meng J,Xu M,Liu M,Qi Y,Tan C,Wang Y,Zhang P,Weng W,Sheng W,Huang M,Wang Z

Thu Feb 08 00:00:00 EST 2018

Uterine and placental distribution of selected extracellular matrix (ECM) components in the dog.

Reproduction (Cambridge, England)

Graubner FR,Boos A,Aslan S,Kücükaslan I,Kowalewski MP

Tue May 01 00:00:00 EDT 2018

Uterine and placental distribution of selected extracellular matrix (ECM) components in the dog.

Reproduction (Cambridge, England)

Graubner FR,Boos A,Aslan S,Kücükaslan I,Kowalewski MP

Tue May 01 00:00:00 EDT 2018

Spatial Control of Primary Ciliogenesis by Subdistal Appendages Alters Sensation-Associated Properties of Cilia.

Developmental cell

Mazo G,Soplop N,Wang WJ,Uryu K,Tsou MF

Mon Nov 21 00:00:00 EST 2016

Spatial Control of Primary Ciliogenesis by Subdistal Appendages Alters Sensation-Associated Properties of Cilia.

Developmental cell

Mazo G,Soplop N,Wang WJ,Uryu K,Tsou MF

Mon Nov 21 00:00:00 EST 2016

ECM1 promotes migration and invasion of hepatocellular carcinoma by inducing epithelial-mesenchymal transition.

World journal of surgical oncology

Chen H,Jia W,Li J

Wed Jul 27 00:00:00 EDT 2016

ECM1 promotes migration and invasion of hepatocellular carcinoma by inducing epithelial-mesenchymal transition.

World journal of surgical oncology

Chen H,Jia W,Li J

Wed Jul 27 00:00:00 EDT 2016

ECM1 promotes migration and invasion of hepatocellular carcinoma by inducing epithelial-mesenchymal transition.

World journal of surgical oncology

Chen H,Jia W,Li J

Wed Jul 27 00:00:00 EDT 2016

ECM1 promotes migration and invasion of hepatocellular carcinoma by inducing epithelial-mesenchymal transition.

World journal of surgical oncology

Chen H,Jia W,Li J

Wed Jul 27 00:00:00 EDT 2016

Differential expression of connective tissue growth factor and extracellular matrix proteins in lichen sclerosus.

Journal of the European Academy of Dermatology and Venereology : JEADV

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Wed Feb 01 00:00:00 EST 2012

Differential expression of connective tissue growth factor and extracellular matrix proteins in lichen sclerosus.

Journal of the European Academy of Dermatology and Venereology : JEADV

Gambichler T,Skrygan M,Czempiel V,Tigges C,Kobus S,Meier JJ,Köhler CU,Scola N,Stücker M,Altmeyer P,Kreuter A

Wed Feb 01 00:00:00 EST 2012

Effects of dehydroepiandrosterone on proliferation, migration, and death of breast cancer cells.

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Sat Jun 25 00:00:00 EDT 2011

Effects of dehydroepiandrosterone on proliferation, migration, and death of breast cancer cells.

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Thu Dec 01 00:00:00 EST 2011

Extracellular matrix protein 1, a novel prognostic factor, is associated with metastatic potential of hepatocellular carcinoma.

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Thu Dec 01 00:00:00 EST 2011

Expression of extracellular matrix proteins in reticular variant of mid-dermal elastolysis.

Journal of the European Academy of Dermatology and Venereology : JEADV

Gambichler T,Stücker M,Kreuter A,Matip R,Gaifullina R,Scola N,Skrygan M

Wed Dec 01 00:00:00 EST 2010

Expression of extracellular matrix proteins in reticular variant of mid-dermal elastolysis.

Journal of the European Academy of Dermatology and Venereology : JEADV

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Wed Dec 01 00:00:00 EST 2010

Phospholipid scramblase 1 is secreted by a lipid raft-dependent pathway and interacts with the extracellular matrix protein 1 in the dermal epidermal junction zone of human skin.