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Product Details
25892-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
EDA Fusion Protein Ag23154 (1-132 aa encoded by BC126143)
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MGYPEVERR ELLPAAAPRE RGSQGCGCGG APARAGEGNS CLLFLGFFGL SLALHLLTLC CYLELRSELR RERGAESRLG GSGTPGTSGT LSSLGGLDPD SPITSHLGQP SPKQQPLEPG EAALHSDSQD GHQ (1-132 aa encoded by BC126143)
Target Information
EDA is a type II membrane protein that can be cleaved by furin to produce a secreted form. This protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in the gene for EDA are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ectodermal dysplasia protein; Ectodysplasin; Ectodysplasin-A; EDA 1; EDA protein; EDA protein homolog; oligodontia 1; Tabby protein; tumor necrosis factor ligand 7C; X-linked anhidroitic ectodermal dysplasia protein
Gene Aliases: ECTD1; ED1; ED1-A1; ED1-A2; EDA; EDA-A1; EDA-A2; EDA1; EDA2; HED; HED1; ODT1; STHAGX1; Ta; tabby; TNLG7C; XHED; XLHED
UniProt ID: (Human) Q92838, (Mouse) O54693
Entrez Gene ID: (Human) 1896, (Mouse) 13607
immune response
cell-matrix adhesion
gene expression
positive regulation of gene expression
cell differentiation
tumor necrosis factor-mediated signaling pathway
positive regulation of NF-kappaB import into nucleus
odontogenesis of dentin-containing tooth
pigmentation
positive regulation of NF-kappaB transcription factor activity
salivary gland cavitation
hair follicle placode formation
trachea gland development
positive regulation of canonical Wnt signaling pathway
hair follicle development
multicellular organism development
positive regulation of I-kappaB kinase/NF-kappaB signaling
skin development
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