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FIGURE: 1 / 2
EDA2R Antibody (H00060401-D01P) in WB
Western Blot analysis of EDA2R expression in transfected 293T cell line (H00060401-T02) by EDA2R MaxPab polyclonal antibody.
Lane 1: EDA2R transfected lysate(32.70 KDa).
Lane 2: Non-transfected lysate.
Lane 1: EDA2R transfected lysate(32.70 KDa).
Lane 2: Non-transfected lysate.
Product Details
H00060401-D01P
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
EDA2R (NP_068555.1, 1 a.a. approximately 297 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MDCQENEYWD QWGRCVTCQR CGPGQELSKD CGYGEGGDAY CTACPPRRYK SSWGHHRCQS CITCAVINRV QKVNCTATSN AVCGDCLPRF YRKTRIGGLQ DQECIPCTKQ TPTSEVQCAF QLSLVEADAP TVPPQEATLV ALVSSLLVVF TLAFLGLFFL YCKQFFNRHC QRGGLLQFEA DKTAKEESLF PVPPSKETSA ESQVSENIFQ TQPLNPILED DCSSTSGFPT QESFTMASCT SESHSHWVHS PIECTELDLQ KFSSSASYTG AETLGGNTVE STGDRLELNV PFEVPSP
Target Information
X-linked ectodysplasin-A2 receptor (XEDAR) is a recently isolated member of the tumor necrosis factor receptor family that is highly expressed during embryonic development and binds to ectodysplatin-A2 (EDA-A2). Two predominantly expressed isoforms, XEDAR-s and XEDAR-L, differ by only a 21-amino region at the juxtamembrane region of the cytoplasmic domain. Neither isoform possesses a death domain and both have been shown to act mainly through TRAF3 and TRAF6 to activate the NF-kappa-B and JNK pathways. Cells transfected with XEDAR and treated with EDA-A2 cause the assembly of a secondary complex containing FADD, caspase-8 and caspase-10, leading to the activation caspase-8 and caspase-3, and finally apoptosis. The EDA-A2-induced apoptosis is dependent on caspase-9 activation, as various pharmacological and genetic inhibitors of caspase-8 blocked apoptosis following EDA-A2 treatment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ectodysplasin A2 isoform receptor; EDA-A2 receptor; Tumor necrosis factor receptor superfamily member 27; tumor necrosis factor receptor superfamily member XEDAR; X linked ectodysplasin receptor; X-linked ectodysplasin-A2 receptor
Gene Aliases: 9430060M22Rik; EDA-A2R; EDA2R; EDAA2R; TNFRSF27; UNQ2448/PRO5727/PRO34080; XEDAR
UniProt ID: (Human) Q9HAV5, (Mouse) Q8BX35
Entrez Gene ID: (Human) 60401, (Mouse) 245527
multicellular organism development
programmed cell death
cell differentiation
positive regulation of JNK cascade
positive regulation of NF-kappaB transcription factor activity
intrinsic apoptotic signaling pathway by p53 class mediator
epidermis development
tissue development
ectodermal cell differentiation
tumor necrosis factor-mediated signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
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