Proteintech

EDNRB Polyclonal Antibody

EDNRB Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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EDNRB Antibody (20964-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human placenta tissue slide using 20964-1-AP ( EDNRB Antibody) at dilution of 1:50 (under 40x lens).

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Product Details

20964-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.14 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Target Information

Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Functions of retinal astrocytes and Müller cells in mammalian myopia.

BMC ophthalmology

Zhang X,Yu X,Wen Y,Jin L,Zhang L,Zhu H,Zhang D,Xie C,Guo D,Tong J,Shen Y

Thu Nov 24 00:00:00 EST 2022

The immunosuppressive role of Edn3 overexpression in the melanoma microenvironment.

Pigment cell & melanoma research

Freitas JT,Lopez J,Llorian C,Boroni M,Kos L

Mon Nov 01 00:00:00 EDT 2021

The immunosuppressive role of Edn3 overexpression in the melanoma microenvironment.

Pigment cell & melanoma research

Freitas JT,Lopez J,Llorian C,Boroni M,Kos L

Mon Nov 01 00:00:00 EDT 2021

Nucleic acid ligands act as a PAM and agonist depending on the intrinsic ligand binding state of P2RY2.

Proceedings of the National Academy of Sciences of the United States of America

Takahashi M,Amano R,Ozawa M,Martinez A,Akita K,Nakamura Y

Tue May 04 00:00:00 EDT 2021

Minimally modified low-density lipoprotein upregulates the ET_B and α₁ receptors in mouse mesenteric arteries in vivo by activating the PI3K/Akt pathway.

The Journal of pharmacy and pharmacology

Zeng ZS,Lin J,Xu CB,Cao L,Chen C,Li J

Sat Jun 01 00:00:00 EDT 2019

Tail vein injection of mmLDL upregulates mouse mesenteric artery ET_B receptors via activation of the ERK1/2 pathway.

Vascular pharmacology

Liu Y,Chen XL,Xu CB,Cao L,Lin J,Chen G,Li J

Fri Sep 01 00:00:00 EDT 2017

Tail vein injection of mmLDL upregulates mouse mesenteric artery ET_B receptors via activation of the ERK1/2 pathway.

Vascular pharmacology

Liu Y,Chen XL,Xu CB,Cao L,Lin J,Chen G,Li J

Fri Sep 01 00:00:00 EDT 2017

Bioinformatics

Protein Aliases: AU022549; endothelin B receptor; Endothelin receptor non-selective type; endothelin receptor subtype B1; Endothelin receptor type B; ET-B; Et-b receptor; Et-b-r; ET-RB; Etb receptor; Etb-svr; piebald; RP11-318G21.1

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Gene Aliases: ABCDS; EDNRB; ET-B; ET-BR; ETB; ETB1; ETBR; ETR-b; ETRB; HSCR; HSCR2; Sox10m1; WS4A

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UniProt ID: (Human) P24530, (Mouse) P48302

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Entrez Gene ID: (Human) 1910, (Mouse) 13618

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Function(s)

endothelin receptor activity protein binding peptide hormone binding type 1 angiotensin receptor binding signal transducer activity G-protein coupled receptor activity

Process(es)

negative regulation of transcription from RNA polymerase II promoter neural crest cell migration positive regulation of protein phosphorylation regulation of pH cell surface receptor signaling pathway negative regulation of adenylate cyclase activity phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration nervous system development peripheral nervous system development posterior midgut development aging regulation of blood pressure positive regulation of cell proliferation negative regulation of neuron maturation response to organic cyclic compound vein smooth muscle contraction sensory perception of pain cGMP-mediated signaling melanocyte differentiation regulation of fever generation negative regulation of cellular protein metabolic process enteric smooth muscle cell differentiation positive regulation of urine volume positive regulation of renal sodium excretion epithelial fluid transport vasoconstriction vasodilation negative regulation of apoptotic process macrophage chemotaxis response to pain enteric nervous system development regulation of epithelial cell proliferation regulation of sensory perception of pain positive regulation of penile erection cellular response to lipopolysaccharide endothelin receptor signaling pathway signal transduction G-protein coupled receptor signaling pathway response to lipopolysaccharide pigmentation developmental pigmentation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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EDNRB Polyclonal Antibody

EDNRB Antibody (20964-1-AP) in IHC (P)

Product Details

20964-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Target Information

Bioinformatics

Performance Guarantee

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