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Product Details
BS-8560R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human ELL3, amino acids 51-158.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Enhancer-binding elongation factor that specifically binds enhancers in embryonic stem cells (ES cells), marks them, and is required for their future activation during stem cell specification. Does not only bind to enhancer regions of active genes, but also marks the enhancers that are in a poised or inactive state in ES cells and is required for establishing proper RNA polymerase II occupancy at developmentally regulated genes in a cohesin-dependent manner. Probably required for priming developmentally regulated genes for later recruitment of the super elongation complex (SEC), for transcriptional activation during differentiation. Required for recruitment of P-TEFb within SEC during differentiation. Probably preloaded on germ cell chromatin, suggesting that it may prime gene activation by marking enhancers as early as in the germ cells. Promoting epithelial-mesenchymal transition (EMT). Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: elongation factor RNA polymerase II-like 3; RNA polymerase II elongation factor ELL3
Gene Aliases: A930015D22Rik; ELL3
UniProt ID: (Human) Q9HB65, (Rat) Q5XFX8, (Mouse) Q80VR2
Entrez Gene ID: (Human) 80237, (Rat) 296102, (Mouse) 269344
DNA-templated transcription, elongation
transcription from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
spermatogenesis
regulation of epithelial to mesenchymal transition
positive regulation of DNA-templated transcription, elongation
snRNA transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter
stem cell differentiation
positive regulation of neurogenesis
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
positive regulation of neural precursor cell proliferation
biological_process
negative regulation of signal transduction by p53 class mediator
transcription, DNA-templated
regulation of transcription, DNA-templated
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