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Product Details
BS-11552R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human EN2/Engrailed 2, amino acids 281-333.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AUTS1; engrailed 2; engrailed homolog 2; engrailed-2; Homeobox protein en-2; Homeobox protein engrailed-2; hu-En-2; mo-En-2
Gene Aliases: BB131122; En-2; EN2; RGD1561842
UniProt ID: (Human) P19622, (Mouse) P09066
Entrez Gene ID: (Human) 2020, (Mouse) 13799, (Rat) 499964
multicellular organism development
midbrain development
hindbrain development
negative regulation of neuron apoptotic process
positive regulation of transcription from RNA polymerase II promoter
neuron development
embryonic brain development
regulation of transcription, DNA-templated
neuron differentiation
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