Proteintech

ENDOG Polyclonal Antibody

FIGURE: 1 / 8

ENDOG Antibody (22148-1-AP) in WB

Various lysates were subjected to SDS PAGE followed by western blot with (Product # 22148-1-AP) ENDOG antibody at dilution of 1:8,000 incubated at room temperature for 1.5 hours.

ENDOG Antibody in Immunoprecipitation (IP)

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Product Details

22148-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 9 publications 9 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ENDOG Fusion Protein Ag17739 (63-297 aa encoded by BC016351)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: ELAKYGLPG LAQLKSRESY VLCYDPRTRG ALWVVEQLRP ERLRGDGDRR ECDFREDDSV HAYHRATNAD YRGSGFDRGH LAAAANHRWS QKAMDDTFYL SNVAPQVPHL NQNAWNNLEK YSRSLTRSYQ NVYVCTGPLF LPRTEADGKS YVKYQVIGKN HVAVPTHFFK VLILEAAGGQ IELRTYVMPN APVDEAIPLE RFLVPIESIE RASGLLFVPN ILARAGSLKA ITAGSK (63-297 aa encoded by BC016351)

Target Information

The protein encoded by this gene is a nuclear encoded endonuclease that is localized in the mitochondrion. The encoded protein is widely distributed among animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Chlorogenic Acid Alleviates Hepatic Ischemia-Reperfusion Injury by Inhibiting Oxidative Stress, Inflammation, and Mitochondria-Mediated Apoptosis In Vivo and In Vitro.

Inflammation

Li K,Feng Z,Wang L,Ma X,Wang L,Liu K,Geng X,Peng C

Thu Jun 01 00:00:00 EDT 2023

Nuclear endonuclease G controls cell proliferation in ovarian cancer.

FEBS open bio

Choi YN,Seo TW,Lee YT,Jeong DH,Yoo SJ

Sat Apr 01 00:00:00 EDT 2023

Nuclear endonuclease G controls cell proliferation in ovarian cancer.

FEBS open bio

Choi YN,Seo TW,Lee YT,Jeong DH,Yoo SJ

Sat Apr 01 00:00:00 EDT 2023

Nuclear endonuclease G controls cell proliferation in ovarian cancer.

FEBS open bio

Choi YN,Seo TW,Lee YT,Jeong DH,Yoo SJ

Sat Apr 01 00:00:00 EDT 2023

Thiamine insufficiency induces Hypoxia Inducible Factor-1α as an upstream mediator for neurotoxicity and AD-like pathology.

Molecular and cellular neurosciences

Valle ML,Anderson YT,Grimsey N,Zastre J

Thu Dec 01 00:00:00 EST 2022

Induction of mitochondrial apoptosis pathway mediated through caspase-8 and c-Jun N-terminal kinase by cadmium-activated Fas in rat cortical neurons.

Metallomics : integrated biometal science

Wen S,Wang L,Zhang W,Xu M,Song R,Zou H,Gu J,Bian J,Yuan Y,Liu Z

Mon Jul 12 00:00:00 EDT 2021

Quercitrin Attenuates Acetaminophen-Induced Acute Liver Injury by Maintaining Mitochondrial Complex I Activity.

Frontiers in pharmacology

Xiong W,Yuan Z,Wang T,Wu S,Xiong Y,Yao Y,Yang Y,Wu H

Wed May 26 00:00:00 EDT 2021

Inhibition of autophagy enhances timosaponin AIII-induced lung cancer cell apoptosis and anti-tumor effect in vitro and in vivo.

Life sciences

Liu J,Deng X,Sun X,Dong J,Huang J

Tue Sep 15 00:00:00 EDT 2020

Proteomics Analysis of Tangeretin-Induced Apoptosis through Mitochondrial Dysfunction in Bladder Cancer Cells.

International journal of molecular sciences

Lin JJ,Huang CC,Su YL,Luo HL,Lee NL,Sung MT,Wu YJ

Tue Feb 26 00:00:00 EST 2019

Emodin Induced SREBP1-Dependent and SREBP1-Independent Apoptosis in Hepatocellular Carcinoma Cells.

Frontiers in pharmacology

Yang N,Li C,Li H,Liu M,Cai X,Cao F,Feng Y,Li M,Wang X

Wed Sep 30 00:00:00 EDT 2020

O-Alkylated derivatives of quercetin induce apoptosis of MCF-7 cells via a caspase-independent mitochondrial pathway.

Chemico-biological interactions

Liao H,Bao X,Zhu J,Qu J,Sun Y,Ma X,Wang E,Guo X,Kang Q,Zhen Y

Sat Dec 05 00:00:00 EST 2015

O-Alkylated derivatives of quercetin induce apoptosis of MCF-7 cells via a caspase-independent mitochondrial pathway.

Chemico-biological interactions

Liao H,Bao X,Zhu J,Qu J,Sun Y,Ma X,Wang E,Guo X,Kang Q,Zhen Y

Sat Dec 05 00:00:00 EST 2015

Bioinformatics

Protein Aliases: Endo G; Endonuclease G, mitochondrial; mitochondrial endonuclease G

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Gene Aliases: ENDOG

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UniProt ID: (Human) Q14249, (Mouse) O08600

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Entrez Gene ID: (Human) 2021, (Mouse) 13804, (Rat) 362100

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Function(s)

nucleic acid binding endonuclease activity deoxyribonuclease activity protein binding metal ion binding nuclease activity hydrolase activity

Process(es)

in utero embryonic development DNA metabolic process DNA catabolic process apoptotic DNA fragmentation response to tumor necrosis factor positive regulation of apoptotic process response to antibiotic nucleic acid phosphodiester bond hydrolysis positive regulation of hydrogen peroxide-mediated programmed cell death positive regulation of apoptotic DNA fragmentation DNA recombination aging response to mechanical stimulus response to estradiol neuron death in response to oxidative stress cellular response to calcium ion cellular response to glucose stimulus cellular response to hypoxia cellular response to oxidative stress

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ENDOG Polyclonal Antibody

ENDOG Antibody (22148-1-AP) in WB

Product Details

22148-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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