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Product Details
BS-11280R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Cat,
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human Endolin 2, amino acids 49-59.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Endothelins are endothelium-derived vasoconstrictor peptides. Endothelin 2, also known as ET-2, is a protein that in humans is encoded by the EDN2 gene. The secreted peptide (~2kD, 21 amino acids) is produced as a result of endothelin-2 precursor (~20 kD) processing and functions as a ligand for endothelin receptors which upon peptide binding modulates a wide array of cell signaling events. Diseases associated with endothelins include aortic disease and patent ductus arteriosus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EDN 2; EDN-2; Endothelin isopeptide 2; Endothelin-2; ET-2; PP ET-2; PPET2; preproendothelin 2; Preproendothelin-2; RNEDN2S01; Vasoactive intestinal contractor; vasoactive intestinal contractor peptide; VIC
Gene Aliases: EDN2; ET-2; ET2; PPET2; VIC
UniProt ID: (Human) P20800, (Cat) Q5NRQ0, (Mouse) P22389
Entrez Gene ID: (Human) 1907, (Cat) 494215, (Rat) 24324, (Mouse) 13615
prostaglandin biosynthetic process
temperature homeostasis
positive regulation of leukocyte chemotaxis
hormonal regulation of the force of heart contraction
positive regulation of the force of heart contraction by chemical signal
regulation of systemic arterial blood pressure by endothelin
cell surface receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
positive regulation of cell proliferation
positive regulation of heart rate
artery smooth muscle contraction
vein smooth muscle contraction
cytokine-mediated signaling pathway
regulation of vasoconstriction
calcium-mediated signaling
neutrophil chemotaxis
macrophage activation
vasoconstriction
positive regulation of smooth muscle contraction
inositol phosphate-mediated signaling
macrophage chemotaxis
lung alveolus development
positive regulation of prostaglandin-endoperoxide synthase activity
energy homeostasis
ovarian follicle rupture
protein kinase C-activating G-protein coupled receptor signaling pathway
regulation of blood pressure
positive regulation of hormone secretion
negative regulation of hormone secretion
regulation of blood vessel size
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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