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EphA6 Antibody (PA5-115187) in IHC (P)
Immunohistochemistry analysis of EphA6 in rat spleen tissue. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-115187) at a dilution of 1:100. Secondary staining was applied with HRP conjugated goat anti-rabbit.
Product Details
PA5-115187
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human EPHA6(Accession Q9UF33), corresponding to amino acid residues S953-R1003.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2899823
Product Specific Information
Antibody detects endogenous levels of total EPHA6.
Target Information
EPHA6 is a member of the ephrin receptor subfamily of protein-tyrosine kinases which have been implicated in axon guidance, neuron-target interactions, regional compartmentalization, and synaptic functions in nervous systems. EPHA6 is highly expressed in the brain and testis. Reduction in EPHA6 has been detected in Hypospadias, a common defect affecting the growth and closure of the external genitalia. Genetic inhibition of EPHA6 in mice produces behavioral deficits specifically in tests of learning and memory. Mice deficient in EPHA6 show reduced memory of the consequences of the training context.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp434C1418; EHK-2; EK12; EPH homology kinase 2; Eph receptor A6; EPH-like kinase 12; ephrin receptor EphA6; Ephrin type-A receptor 6; FLJ35246; tyrosine-protein kinase receptor EHK-2
Gene Aliases: EHK-2; EHK2; EK12; EPA6; EPHA6; HEK12; m-ehk2; PRO57066
UniProt ID: (Human) Q9UF33
Entrez Gene ID: (Human) 285220, (Rat) 29202, (Mouse) 13840
molecular_function
ephrin receptor activity
ATP binding
protein kinase activity
nucleotide binding
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
transmembrane signal receptor
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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