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Product Details
MA5-30425
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
014
Immunogen
Recombinant Human FGF10/KGF2 Protein (Gln38-Ser208)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2786156
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
This antibody has specificity for Human FGF10/KGF2.
Target Information
FGF10 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This protein is also implicated to be a primary factor in the process of wound healing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FGF; FGF-10; Fibroblast growth factor; Fibroblast growth factor 10; Keratinocyte growth factor 2; produced by fibroblasts of urinary bladder lamina propria
Gene Aliases: FGF10
UniProt ID: (Human) O15520
Entrez Gene ID: (Human) 2255
protein tyrosine kinase activity
Ras guanyl-nucleotide exchange factor activity
fibroblast growth factor receptor binding
type 2 fibroblast growth factor receptor binding
protein binding
growth factor activity
heparin binding
1-phosphatidylinositol-3-kinase activity
chemoattractant activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
growth factor
intercellular signal molecule
establishment of mitotic spindle orientation
MAPK cascade
activation of MAPK activity
angiogenesis
metanephros development
organ induction
mesonephros development
blood vessel remodeling
metanephros morphogenesis
determination of left/right symmetry
salivary gland development
negative regulation of cell proliferation
fibroblast growth factor receptor signaling pathway
regulation of smoothened signaling pathway
embryonic pattern specification
epithelial cell migration
positive regulation of epithelial cell migration
positive regulation of keratinocyte proliferation
regulation of phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
pituitary gland development
embryonic genitalia morphogenesis
thyroid gland development
otic vesicle formation
positive regulation of vascular endothelial growth factor receptor signaling pathway
pancreas development
hair follicle morphogenesis
embryonic camera-type eye development
actin cytoskeleton reorganization
positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
response to estradiol
response to lipopolysaccharide
positive regulation of ATPase activity
lacrimal gland development
regulation of activin receptor signaling pathway
protein localization to cell surface
somatic stem cell population maintenance
phosphatidylinositol-3-phosphate biosynthetic process
wound healing
tissue regeneration
odontogenesis of dentin-containing tooth
muscle cell fate commitment
positive regulation of MAPK cascade
positive regulation of GTPase activity
keratinocyte proliferation
negative regulation of cell differentiation
positive regulation of DNA repair
positive regulation of DNA replication
positive regulation of Notch signaling pathway
positive regulation of transcription, DNA-templated
positive regulation of mitotic cell cycle
positive regulation of transcription from RNA polymerase II promoter
positive regulation of Ras protein signal transduction
phosphatidylinositol phosphorylation
regulation of saliva secretion
phosphatidylinositol-mediated signaling
positive regulation of fibroblast proliferation
spleen development
thymus development
embryonic digestive tract morphogenesis
branching morphogenesis of an epithelial tube
female genitalia morphogenesis
male genitalia morphogenesis
positive regulation of lymphocyte proliferation
epithelial cell proliferation
urothelial cell proliferation
positive regulation of urothelial cell proliferation
positive regulation of epithelial cell proliferation
positive regulation of peptidyl-tyrosine phosphorylation
white fat cell differentiation
positive chemotaxis
induction of positive chemotaxis
smooth muscle cell differentiation
positive regulation of keratinocyte migration
radial glial cell differentiation
positive regulation of epithelial cell proliferation involved in wound healing
limb bud formation
lung epithelium development
lung saccule development
bronchiole morphogenesis
bud outgrowth involved in lung branching
bud elongation involved in lung branching
mesenchymal-epithelial cell signaling involved in lung development
Type II pneumocyte differentiation
prostatic bud formation
fibroblast growth factor receptor signaling pathway involved in mammary gland specification
mammary gland bud formation
submandibular salivary gland formation
epithelial cell proliferation involved in salivary gland morphogenesis
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
branch elongation involved in salivary gland morphogenesis
semicircular canal fusion
mesenchymal cell differentiation involved in lung development
secretion by lung epithelial cell involved in lung growth
lung proximal/distal axis specification
tear secretion
positive regulation of white fat cell proliferation
ERK1 and ERK2 cascade
positive regulation of ERK1 and ERK2 cascade
Harderian gland development
negative regulation of cell cycle arrest
positive regulation of hair follicle cell proliferation
positive regulation of canonical Wnt signaling pathway
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
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