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Product Details
PA5-67182
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human FGF12. Recombinant protein control fragment (Product #RP-107824).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2663036
Product Specific Information
Immunogen sequence: EPSLHEIGEKQ GRSRKSSGTP TMNGGKVVNQ DS
Highest antigen sequence identity to the following orthologs - mouse 100%, rat 100%.
Target Information
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FGF; FGF-12; FHF-1; Fibroblast growth factor; Fibroblast growth factor 12; fibroblast growth factor 12B; fibroblast growth factor FGF-12b; Fibroblast growth factor homologous factor 1; Myocyte-activating factor
Gene Aliases: FGF12; FGF12B; FHF1
UniProt ID: (Human) P61328
Entrez Gene ID: (Human) 2257
regulation of membrane depolarization
signal transduction
cell-cell signaling
chemical synaptic transmission
nervous system development
heart development
adult locomotory behavior
fibroblast growth factor receptor signaling pathway
positive regulation of sodium ion transport
neuromuscular process
cardiac muscle cell action potential involved in contraction
regulation of neuronal action potential
regulation of sodium ion transmembrane transport
regulation of voltage-gated sodium channel activity
regulation of sodium ion transmembrane transporter activity
negative regulation of cation channel activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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