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Product Details
60152-1-IG
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
2F11A10
Immunogen
FGF12 Fusion Protein Ag5046 (1-181 aa encoded by BC022524)
Conjugate
Form
Liquid
Concentration
1.2 mg/mL
Purification
Caprylic acid precipitation
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MESKEPQLK GIVTRLFSQQ GYFLQMHPDG TIDGTKDENS DYTLFNLIPV GLRVVAIQGV KASLYVAMNG EGYLYSSDVF TPECKFKESV FENYYVIYSS TLYRQQESGR AWFLGLNKEG QIMKGNRVKK TKPSSHFVPK PIEVCMYREQ SLHEIGEKQG RSRKSSGTPT MNGGKVVNQD ST (1-181 aa encoded by BC022524)
Target Information
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FGF; FGF-12; FHF-1; Fibroblast growth factor; Fibroblast growth factor 12; fibroblast growth factor 12B; fibroblast growth factor FGF-12b; Fibroblast growth factor homologous factor 1; Myocyte-activating factor
Gene Aliases: FGF12; FGF12B; FHF1
UniProt ID: (Human) P61328
Entrez Gene ID: (Human) 2257
regulation of membrane depolarization
signal transduction
cell-cell signaling
chemical synaptic transmission
nervous system development
heart development
adult locomotory behavior
fibroblast growth factor receptor signaling pathway
positive regulation of sodium ion transport
neuromuscular process
cardiac muscle cell action potential involved in contraction
regulation of neuronal action potential
regulation of sodium ion transmembrane transport
regulation of voltage-gated sodium channel activity
regulation of sodium ion transmembrane transporter activity
negative regulation of cation channel activity
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