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FOSL2 Antibody (CF809660) in IHC (P)
Immunohistochemical staining of paraffin-embedded human lymph node tissue within the normal limits using anti-FOSL2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA809660)(1:2000).
Product Details
CF809660
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI2B4
Immunogen
Human recombinant protein fragment corresponding to amino acids 110-326 of human FOSL2 produced in E.coli.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FOS like 2, AP-1 trancription factor subunit; FOS like antigen 2; FOS-like antigen 2; Fos-related antigen 2; FRA-2
Gene Aliases: FOSL2; Fra-2; FRA2
UniProt ID: (Human) P15408, (Mouse) P47930, (Rat) P51145
Entrez Gene ID: (Human) 2355, (Mouse) 14284, (Rat) 25446
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
RNA polymerase II regulatory region sequence-specific DNA binding
DNA binding
double-stranded DNA binding
sequence-specific DNA binding
transcription regulatory region DNA binding
protein heterodimerization activity
basic leucine zipper transcription factor
keratinocyte development
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
cell death
positive regulation of transcription from RNA polymerase II promoter
positive regulation of fibroblast proliferation
response to hypoxia
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
response to estradiol
positive regulation of transcription, DNA-templated
conditioned taste aversion
female pregnancy
aging
circadian rhythm
response to cold
response to light stimulus
response to mechanical stimulus
response to toxic substance
photoperiodism
response to organic cyclic compound
sleep
response to progesterone
response to cytokine
response to immobilization stress
response to peptide hormone
response to cAMP
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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