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Product Details
PA5-33549
Product Specifications
Species Reactivity
Bat,
Bovine,
Dog,
Horse,
Hamster,
Human,
Mouse,
Non-human primate,
Rabbit,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 17 amino acid peptide from N-terminal extracellular domain of human FZD1 / Frizzled 1.
Conjugate
Form
Liquid
Concentration
0.7 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2550929
Target Information
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Chfz-1; Dfrizzled-1; DKFZp564G072; Drosophila polarity gene (frizzled) homologue; Drosophila polarity gene homolog 1; FLJ95923; frizzled; frizzled 1; frizzled 1, seven transmembrane spanning receptor; frizzled 2; frizzled class receptor 1; frizzled family receptor 1; frizzled homolog 1; frizzled, Drosophila, homolog of, 1; Frizzled-1; Fz receptor 1; Fz-1; Fzd1; FzE1; hFz1; mFz1; rFz1; Wnt receptor; Xfrizzled-1
Gene Aliases: AW227548; Frizzled-1; FZ-1; Fz1; FZD1; I79_011477
UniProt ID: (Human) Q9UP38, (Mouse) O70421
G-protein coupled receptor activity
receptor binding
frizzled binding
protein binding
Wnt-protein binding
PDZ domain binding
Wnt-activated receptor activity
identical protein binding
protein homodimerization activity
protein heterodimerization activity
signal transducer activity
transmembrane signaling receptor activity
transmembrane signal receptor
positive regulation of protein phosphorylation
membranous septum morphogenesis
muscular septum morphogenesis
outflow tract morphogenesis
G-protein coupled receptor signaling pathway
cell-cell signaling
synapse assembly
neuron differentiation
negative regulation of BMP signaling pathway
epithelial cell differentiation
negative regulation of catenin import into nucleus
autocrine signaling
non-canonical Wnt signaling pathway
response to drug
canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation
canonical Wnt signaling pathway involved in osteoblast differentiation
regulation of osteoblast differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
lung alveolus development
positive regulation of sequence-specific DNA binding transcription factor activity
hard palate development
canonical Wnt signaling pathway
Wnt signaling pathway, planar cell polarity pathway
cellular response to vitamin D
cellular response to growth factor stimulus
cellular response to peptide hormone stimulus
negative regulation of canonical Wnt signaling pathway
planar cell polarity pathway involved in neural tube closure
beta-catenin destruction complex disassembly
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
Wnt signaling pathway
ventricular septum morphogenesis
signal transduction
cell surface receptor signaling pathway
multicellular organism development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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