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Product Details
MA5-31147
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
109
Immunogen
Recombinant Mouse Frizzled-1/FZD1 protein (Met1-His248)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2786797
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
This antibody has specificity for Mouse Frizzled-1/FZD1.
Target Information
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Chfz-1; Dfrizzled-1; DKFZp564G072; FLJ95923; frizzled; frizzled 1; Frizzled-1; Fz receptor 1; Fz-1; mFz1; Xfrizzled-1
Gene Aliases: AW227548; FZ-1; Fz1; Fzd1
UniProt ID: (Mouse) O70421
Entrez Gene ID: (Mouse) 14362
signal transducer activity
transmembrane signaling receptor activity
G-protein coupled receptor activity
receptor binding
frizzled binding
Wnt-protein binding
PDZ domain binding
identical protein binding
protein homodimerization activity
Wnt-activated receptor activity
protein heterodimerization activity
transmembrane signal receptor
positive regulation of protein phosphorylation
membranous septum morphogenesis
muscular septum morphogenesis
outflow tract morphogenesis
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
cell-cell signaling
multicellular organism development
Wnt signaling pathway
negative regulation of BMP signaling pathway
epithelial cell differentiation
negative regulation of catenin import into nucleus
autocrine signaling
response to drug
canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation
canonical Wnt signaling pathway involved in osteoblast differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of sequence-specific DNA binding transcription factor activity
hard palate development
canonical Wnt signaling pathway
ventricular septum morphogenesis
negative regulation of canonical Wnt signaling pathway
planar cell polarity pathway involved in neural tube closure
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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