Alomone Labs, LTD

Frizzled-1 (FZD1) (extracellular) Polyclonal Antibody

View all (10) FZD1 antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

AFR-041-200UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200
-

Flow Cytometry (Flow)

2.5 µg
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

(C)PEFWTSNPQHGGG, corresponding to amino acid residues 238-250 of rat Frizzled-1, Extracellular, N-terminus
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.8 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Information

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Chfz-1; Dfrizzled-1; DKFZp564G072; Drosophila polarity gene (frizzled) homologue; Drosophila polarity gene homolog 1; FLJ95923; frizzled; frizzled 1; frizzled 1, seven transmembrane spanning receptor; frizzled family receptor 1; frizzled homolog 1; frizzled, Drosophila, homolog of, 1; Frizzled-1; Fz receptor 1; Fz-1; FzE1; hFz1; mFz1; rFz1; Wnt receptor; Xfrizzled-1

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Gene Aliases: AW227548; FZ-1; Fz1; FZD1

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UniProt ID: (Human) Q9UP38, (Mouse) O70421

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Entrez Gene ID: (Human) 8321, (Rat) 58868, (Mouse) 14362

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Function(s)
G-protein coupled receptor activity receptor binding frizzled binding protein binding Wnt-protein binding PDZ domain binding Wnt-activated receptor activity identical protein binding protein homodimerization activity protein heterodimerization activity signal transducer activity transmembrane signaling receptor activity transmembrane signal receptor
Process(es)
positive regulation of protein phosphorylation membranous septum morphogenesis muscular septum morphogenesis outflow tract morphogenesis G-protein coupled receptor signaling pathway cell-cell signaling synapse assembly neuron differentiation negative regulation of BMP signaling pathway epithelial cell differentiation negative regulation of catenin import into nucleus autocrine signaling non-canonical Wnt signaling pathway response to drug canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation canonical Wnt signaling pathway involved in osteoblast differentiation regulation of osteoblast differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated lung alveolus development positive regulation of sequence-specific DNA binding transcription factor activity hard palate development canonical Wnt signaling pathway Wnt signaling pathway, planar cell polarity pathway cellular response to vitamin D cellular response to growth factor stimulus cellular response to peptide hormone stimulus negative regulation of canonical Wnt signaling pathway planar cell polarity pathway involved in neural tube closure beta-catenin destruction complex disassembly Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation Wnt signaling pathway ventricular septum morphogenesis signal transduction cell surface receptor signaling pathway multicellular organism development
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