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Product Details
PA5-120612
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human Fyn (NP_002028.1).
Conjugate
Form
Liquid
Concentration
0.88 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2914184
Product Specific Information
Positive test controls include: Mouse testis, Mouse brain, Rat brain. The target is usually found in the following locations: Cell membrane, Cytoplasm, Nucleus.
Immunogen sequence: VKHYKIRKLD NGGYYITTRA QFETLQQLVQ HYSERAAGLC CRLVVPCHKG MPRLTDLSVK TKDVWEIPRE SLQLIKRLGN GQFGEVWMGT WNGNTKVAIK T
Target Information
FYN is a SRC-related kinase expressed in brain, skeletal muscle and adipose tissues. Fyn functions in a large number of pathways and has been shown to play a role in memory. FYN is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C syn protooncogene; c-syn protooncogene; EC 2.7.10.2; FYN oncogene related to SRC, FGR, YES; fyn {ECO:0000312|RGD:2641}; kinase Fyn; MGC45350; OKT3-induced calcium influx regulator; OTTHUMP00000017916; OTTHUMP00000017917; P59 p59-Fyn; p59-Fyn; Proto-oncogene c-Fyn; Proto-oncogene Syn; proto-oncogene tyrosine-protein kinase Fyn; Protooncogene Syn; RP1-66H14.1; SLK; Src Kinase p59; Src like kinase; Src-like kinase; src/yes-related novel; tyrosine kinase p59fyn(T); Tyrosine-protein kinase Fyn
Gene Aliases: AI448320; AW552119; FYN; p59-FYN; SLK; SYN
UniProt ID: (Human) P06241, (Rat) Q62844, (Mouse) P39688
Entrez Gene ID: (Human) 2534, (Rat) 25150, (Mouse) 14360
G-protein coupled receptor binding
glycoprotein binding
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
Ras guanyl-nucleotide exchange factor activity
protein binding
ATP binding
tubulin binding
T cell receptor binding
CD4 receptor binding
CD8 receptor binding
phosphatidylinositol 3-kinase binding
ion channel binding
metal ion binding
ephrin receptor binding
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
peptide hormone receptor binding
growth factor receptor binding
protein kinase activity
receptor binding
protein complex binding
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase modulator
MAPK cascade
neuron migration
stimulatory C-type lectin receptor signaling pathway
adaptive immune response
protein phosphorylation
calcium ion transport
transmembrane receptor protein tyrosine kinase signaling pathway
axon guidance
central nervous system development
blood coagulation
learning
feeding behavior
regulation of cell shape
negative regulation of gene expression
positive regulation of neuron projection development
regulation of phosphatidylinositol 3-kinase signaling
positive regulation of phosphatidylinositol 3-kinase signaling
viral process
cell migration
peptidyl-tyrosine phosphorylation
cell differentiation
platelet activation
forebrain development
T cell costimulation
negative regulation of protein ubiquitination
intracellular signal transduction
cellular response to platelet-derived growth factor stimulus
peptidyl-tyrosine autophosphorylation
Fc-gamma receptor signaling pathway involved in phagocytosis
T cell activation
regulation of cell proliferation
negative regulation of protein catabolic process
response to drug
positive regulation of tyrosine phosphorylation of Stat5 protein
regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of neuron apoptotic process
positive regulation of GTPase activity
innate immune response
response to ethanol
phosphatidylinositol phosphorylation
vascular endothelial growth factor receptor signaling pathway
ephrin receptor signaling pathway
phosphatidylinositol-mediated signaling
dendrite morphogenesis
regulation of defense response to virus by virus
activated T cell proliferation
T cell receptor signaling pathway
leukocyte migration
detection of mechanical stimulus involved in sensory perception of pain
cellular response to peptide hormone stimulus
cellular response to transforming growth factor beta stimulus
positive regulation of protein localization to nucleus
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
cell surface receptor signaling pathway
ionotropic glutamate receptor signaling pathway
protein autophosphorylation
cellular response to growth factor stimulus
immune system process
multicellular organism development
phosphorylation
myelination
Performance Guarantee
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