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Fyn Antibody (MA5-49940) in IHC (P)
Immunohistochemistry analysis with a Fyn monoclonal antibody (Product # MA5-49940) using a dilution of 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30 min at RT. Then primary antibody (1% BSA) was incubat... View More
Product Details
MA5-49940
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
1G3
Immunogen
A synthesized peptide derived from human Fyn
Conjugate
Form
Liquid
Concentration
2 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Wet ice
RRID
AB_3092746
Target Information
FYN is a SRC-related kinase expressed in brain, skeletal muscle and adipose tissues. Fyn functions in a large number of pathways and has been shown to play a role in memory. FYN is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C syn protooncogene; c-syn protooncogene; EC 2.7.10.2; FYN oncogene related to SRC, FGR, YES; kinase Fyn; MGC45350; OKT3-induced calcium influx regulator; OTTHUMP00000017916; OTTHUMP00000017917; P59 p59-Fyn; p59-Fyn; Proto-oncogene c-Fyn; Proto-oncogene Syn; Protooncogene Syn; RP1-66H14.1; SLK; Src like kinase; Src-like kinase; src/yes-related novel; tyrosine kinase p59fyn(T); Tyrosine-protein kinase Fyn
Gene Aliases: FYN; p59-FYN; SLK; SYN
UniProt ID: (Human) P06241
Entrez Gene ID: (Human) 2534
G-protein coupled receptor binding
glycoprotein binding
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
Ras guanyl-nucleotide exchange factor activity
protein binding
ATP binding
tubulin binding
T cell receptor binding
CD4 receptor binding
CD8 receptor binding
phosphatidylinositol 3-kinase binding
ion channel binding
metal ion binding
ephrin receptor binding
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
peptide hormone receptor binding
growth factor receptor binding
kinase modulator
MAPK cascade
neuron migration
stimulatory C-type lectin receptor signaling pathway
adaptive immune response
protein phosphorylation
calcium ion transport
transmembrane receptor protein tyrosine kinase signaling pathway
axon guidance
central nervous system development
blood coagulation
learning
feeding behavior
regulation of cell shape
negative regulation of gene expression
positive regulation of neuron projection development
regulation of phosphatidylinositol 3-kinase signaling
positive regulation of phosphatidylinositol 3-kinase signaling
viral process
cell migration
peptidyl-tyrosine phosphorylation
cell differentiation
platelet activation
forebrain development
T cell costimulation
negative regulation of protein ubiquitination
intracellular signal transduction
cellular response to platelet-derived growth factor stimulus
peptidyl-tyrosine autophosphorylation
Fc-gamma receptor signaling pathway involved in phagocytosis
T cell activation
regulation of cell proliferation
negative regulation of protein catabolic process
response to drug
positive regulation of tyrosine phosphorylation of Stat5 protein
regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of neuron apoptotic process
positive regulation of GTPase activity
innate immune response
response to ethanol
phosphatidylinositol phosphorylation
vascular endothelial growth factor receptor signaling pathway
ephrin receptor signaling pathway
phosphatidylinositol-mediated signaling
dendrite morphogenesis
regulation of defense response to virus by virus
activated T cell proliferation
T cell receptor signaling pathway
leukocyte migration
detection of mechanical stimulus involved in sensory perception of pain
cellular response to peptide hormone stimulus
cellular response to transforming growth factor beta stimulus
positive regulation of protein localization to nucleus
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
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