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Alomone Labs, LTD
GABA(B) Receptor 1 (extracellular) Polyclonal Antibody, FITC
FIGURE: 1 / 2
GABA(B) Receptor 1 (extracellular) Antibody (AGB-001-F-50UL) in Flow
Cell surface detection of GABA (B) Receptor 1 by direct flow cytometry in live intact human THP-1 monocytic leukemia cells: - (black line) cells. (red) Cells + Rabbit IgG Isotype Control-FITC. (green) Cells + Anti-GABA (B) Receptor 1 (extracellular)-FITC Antibody (#AGB-001-F), (5 µg).
Product Details
AGB-001-F-50UL
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CRGEREVVGPKVRK, corresponding to amino acid residues 66-79 of rat GABBR1, Extracellular, N-terminus
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Lyophilized
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 15 µL or 50 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bM573K1.1.1 (gamma-aminobutyric acid (GABA) B receptor, 1a); DAAP-188P13.3; dJ271M21.1.1; dJ271M21.1.2; FLJ92613; GABA(B) receptor; GABA-B receptor 1; GABA-B receptor, R1 subunit; GABA-B-R1; Gaba-b-r1a; Gaba-b1; GABA-BR1; Gaba-br1a receptor; GABA-BR1b receptor; GABAB; GABABR1; Gababr1 receptor; gamma-aminobutyric acid; gamma-aminobutyric acid (GABA) B receptor, 1; gamma-aminobutyric acid (GABA-B) receptor, 1; Gamma-aminobutyric acid type B receptor subunit 1; gb1; GBR1; HGB1a; OTTHUMP00000109099; OTTHUMP00000214725; seven transmembrane helix receptor
Gene Aliases: bM573K1.1; GABAB1; GABABR1; GABBR1; GABBR1-3; GB1; GPRC3A
UniProt ID: (Human) Q9UBS5, (Mouse) Q9WV18, (Rat) Q9Z0U4
Entrez Gene ID: (Human) 2550, (Mouse) 54393, (Rat) 81657
osteoblast differentiation
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
negative regulation of adenylate cyclase activity
gamma-aminobutyric acid signaling pathway
negative regulation of cell proliferation
positive regulation of glutamate secretion
negative regulation of gamma-aminobutyric acid secretion
negative regulation of epinephrine secretion
negative regulation of dopamine secretion
response to nicotine
response to ethanol
negative regulation of synaptic transmission
positive regulation of growth hormone secretion
signal transduction
G-protein coupled receptor signaling pathway
regulation of glutamate secretion
regulation of cAMP biosynthetic process
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