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Product Details
21542-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GABPA Fusion Protein Ag16191 (1-321 aa encoded by BC035031)
Conjugate
Form
Liquid
Concentration
0.21 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MTKREAEEL IEIEIDGTEK AECTEESIVE QTYAPAECVS QAIDINEPIG NLKKLLEPRL QCSLDAHEIC LQDIQLDPER SLFDQGVKTD GTVQLSVQVI SYQGIEPKLN ILEIVKPADT VEVVIDPDAH HAESEAHLVE EAQVITLDGT KHITTISDET SEQVTRWAAA LEGYRKEQER LGIPYDPIQW STDQVLHWVV WVMKEFSMTD IDLTTLNISG RELCSLNQED FFQRVPRGEI LWSHLELLRK YVLASQEQQM NEIVTIDQPV QIIPASVQSA TPTTIKVINS SAKAAKVQRA PRISGEDRSS PGNRTGNNGQ IQ (1-321 aa encoded by BC035031)
Target Information
This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype. Two transcript variants encoding the same protein have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: GA binding protein transcription factor alpha subunit 60kDa; GA binding protein transcription factor, alpha subunit 60kDa; GA repeat binding protein alpha; GA repeat binding protein, alpha; GA-binding protein alpha chain; GA-binding protein alpha-subunit; GABP subunit alpha; human nuclear respiratory factor-2 subunit alpha; nuclear respiratory factor 2 alpha; nuclear respiratory factor 2 alpha subunit; Nuclear respiratory factor 2 subunit alpha; Transcription factor E4TF1-60
Gene Aliases: E4TF1-60; E4TF1A; GABPA; GABPalpha; NFT2; Nrf-2alpha; NRF2; NRF2A; RCH04A07
UniProt ID: (Human) Q06546, (Mouse) Q00422
Entrez Gene ID: (Human) 2551, (Rat) 363735, (Mouse) 14390
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
protein binding
transcription regulatory region DNA binding
protein heterodimerization activity
RNA polymerase II transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
winged helix/forkhead transcription factor
negative regulation of transcription from RNA polymerase II promoter
in utero embryonic development
transcription from RNA polymerase II promoter
mitochondrion organization
cell differentiation
negative regulation of megakaryocyte differentiation
positive regulation of transcription from RNA polymerase II promoter
regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
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