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GABRA4 Antibody (PA5-116437) in IHC (P)
Immunohistochemical analysis of GABRA4 in a paraffin-embedded mouse brain tissue using a GABRA4 polyclonal antibody (Product #PA5-116437). The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 8.0-8.4) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (1:50) for 30 ... View More
Product Details
PA5-116437
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide within mouse GABRA4 aa 19-68
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 0.2% BSA, 50% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2901069
Product Specific Information
Positive controls: SH-SY5Y cell lysates, rat brain tissue, mouse brain tissue, SH-SY5Y.
Target Information
Gamma-aminobutyric acid is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1. Alternatively spliced transcript variants encoding different isoforms have been found in this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GABA(A) receptor subunit alpha-4; GABA(A) receptor, alpha 4; GABA-A receptor alpha-4 subunit; GABAAR subunit alpha-4; GABAARalpha4; gamma-aminobutyric acid; gamma-aminobutyric acid (GABA) A receptor, alpha 4; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 4; gamma-aminobutyric acid A receptor alpha 4; Gamma-aminobutyric acid receptor subunit alpha-4
Gene Aliases: Gabra-4; GABRA4
UniProt ID: (Human) P48169, (Mouse) Q9D6F4, (Rat) P28471
Entrez Gene ID: (Human) 2557, (Mouse) 14397, (Rat) 140675
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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