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GABRA5 Antibody (PA5-116484) in IHC (P)
Immunohistochemical analysis of GABRA5 in a paraffin-embedded rat brain using a GABRA5 polyclonal antibody (Product #PA5-116484). The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes (sodium citrate buffer (pH6) for 20 mins). The tissues were blocked in 10% negative goat serum for 1 hour at room temperature, washed with PBS, and then probed with the... View More
Product Details
PA5-116484
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide within mouse GABRA5 aa 346-395
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 0.2% BSA, 50% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2901115
Product Specific Information
Positive controls: Rat brain tissue lysates, rat brain tissue, mouse brain tissue, A549.
Target Information
GABRA5 is a part of GABA, a major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GABA(A) receptor subunit alpha-5; GABA-A receptor alpha-5 subunit; GABAA receptor alpha5 subunit; GABAAR subunit alpha-5; gamma-aminobutyric acid; gamma-aminobutyric acid A receptor, alpha 5; gamma-aminobutyric acid (GABA) A receptor, alpha 5; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 5; gamma-aminobutyric acid A receptor, alpha 5; Gamma-aminobutyric acid receptor subunit alpha-5; ligand-gated ion channel subunit
Gene Aliases: A230018I05Rik; Gabra-5; GABRA5
UniProt ID: (Human) P31644, (Rat) P19969, (Mouse) Q8BHJ7
Entrez Gene ID: (Human) 2558, (Rat) 29707, (Mouse) 110886
behavioral fear response
positive regulation of defense response to virus by host
transport
signal transduction
gamma-aminobutyric acid signaling pathway
chemical synaptic transmission
brain development
sensory perception of sound
associative learning
ion transmembrane transport
negative regulation of neuron apoptotic process
inner ear receptor cell development
innervation
cochlea development
mitophagy in response to mitochondrial depolarization
xenophagy
chloride transmembrane transport
regulation of neuron apoptotic process
neuron development
ion transport
chloride transport
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