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GAK Antibody (PA5-15321) in IHC (P)
Immunohistochemistry analysis of GAK in formalin-fixed and paraffin-embedded human cancer tissue. Samples were incubated with GAK polyclonal antibody (Product # PA5-15321) which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatoca... View More
Product Details
PA5-15321
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 1140-1170 amino acids from the C-terminal region of human GAK
Conjugate
Form
Liquid
Concentration
2 mg/mL
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_10987345
Product Specific Information
This antibody is predicted to react with rat based on sequence homology.
Target Information
GAK serine/threonine kinase or Cyclin-G-associated kinase was originally identified as a protein that is associated with cyclin G. However, neither CDK5 nor GAK kinase activity is activated by cyclin G nor does GAK affect CDK5 kinase activity. GAK seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: auxilin-2; Cyclin-G-associated kinase; DnaJ homolog subfamily C member 26
Gene Aliases: D130045N16Rik; DNAJ26; DNAJC26; GAK
UniProt ID: (Human) O14976, (Mouse) Q99KY4
Entrez Gene ID: (Human) 2580, (Mouse) 231580
protein phosphorylation
receptor-mediated endocytosis
endoplasmic reticulum organization
Golgi organization
cell cycle
negative regulation of neuron projection development
clathrin coat disassembly
clathrin-mediated endocytosis
establishment of protein localization to Golgi
establishment of protein localization to plasma membrane
Golgi to lysosome transport
epidermal cell differentiation
phosphorylation
intrahepatic bile duct development
cell development
forebrain morphogenesis
establishment of skin barrier
positive regulation of neural precursor cell proliferation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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