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Product Details
OPA1-15410
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Sheep
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide (KLH conjugated) to the 7th transmembrane domain.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2109152
Product Specific Information
By immunohistochemistry, OPA1-15410 detects GalR2 in formalin fixed, paraffin embedded human tissues.
Target Information
GalR2 expression has been documented widely in the brain and in peripheral tissues including small intestine, heart, kidney, and liver. Localization data from rat CNS indicate high levels of expression in dorsal root ganglia, amygdala, and Purkinje neurons. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Gal receptor 2; Gal-2 receptor; Gal-r2; GAL2-R; Galanin r2 receptor; Galanin receptor type 2; Galanin-2 receptor; MGC125983; MGC125984
Gene Aliases: GAL2-R; GALNR2; GALR-2; GALR2
UniProt ID: (Human) O43603
Entrez Gene ID: (Human) 8811
muscle contraction
cell surface receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
negative regulation of adenylate cyclase activity
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
neuropeptide signaling pathway
chemical synaptic transmission
multicellular organism development
digestion
learning or memory
feeding behavior
neuron projection development
inositol phosphate metabolic process
positive regulation of transcription from RNA polymerase II promoter
phosphatidylinositol metabolic process
positive regulation of large conductance calcium-activated potassium channel activity
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