Proteintech

GCGR Polyclonal Antibody

GCGR Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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GCGR Antibody (26784-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human skeletal muscle tissue slide using 26784-1-AP (GCGR antibody) at dilution of 1:200 (under 40x lens).

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Product Details

26784-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Not Applicable

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

GCGR Fusion Protein Ag24861 (91-141 aa encoded by BC104854)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.37 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: VQHRFVFKR CGPDGQWVRG PRGQPWRDAS QCQMDGEEIE VQKEVAKMYS SF (91-141 aa encoded by BC104854)

Target Information

Glucagon receptors are G-protein coupled receptors for glucagon and play a central role in the regulation of blood glucose levels and glucose homeostatsis. It regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Glucagon receptors also play an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G-proteins) and modulates the activity of down-stream effectors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Glucagon receptor blockage inhibits β-cell dedifferentiation through FoxO1.

American journal of physiology. Endocrinology and metabolism

Wang K,Cui X,Li F,Xia L,Wei T,Liu J,Fu W,Yang J,Hong T,Wei R

Sun Jan 01 00:00:00 EST 2023

Glucagon receptor blockage inhibits β-cell dedifferentiation through FoxO1.

American journal of physiology. Endocrinology and metabolism

Wang K,Cui X,Li F,Xia L,Wei T,Liu J,Fu W,Yang J,Hong T,Wei R

Sun Jan 01 00:00:00 EST 2023

Pro-α-cell-derived β-cells contribute to β-cell neogenesis induced by antagonistic glucagon receptor antibody in type 2 diabetic mice.

iScience

Cui X,Feng J,Wei T,Gu L,Wang D,Lang S,Yang K,Yang J,Yan H,Wei R,Hong T

Fri Jul 15 00:00:00 EDT 2022

Pro-α-cell-derived β-cells contribute to β-cell neogenesis induced by antagonistic glucagon receptor antibody in type 2 diabetic mice.

iScience

Cui X,Feng J,Wei T,Gu L,Wang D,Lang S,Yang K,Yang J,Yan H,Wei R,Hong T

Fri Jul 15 00:00:00 EDT 2022

Mof acetyltransferase inhibition ameliorates glucose intolerance and islet dysfunction of type 2 diabetes via targeting pancreatic α-cells.

Molecular and cellular endocrinology

Guo X,Cui C,Song J,He Q,Zang N,Hu H,Wang X,Li D,Wang C,Hou X,Li X,Liang K,Yan F,Chen L

Mon Nov 01 00:00:00 EDT 2021

Si-Miao-Yong-An decoction preserves cardiac function and regulates GLC/AMPK/NF-κB and GLC/PPARα/PGC-1α pathways in diabetic mice.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Li L,Chen X,Su C,Wang Q,Li R,Jiao W,Luo H,Tian Y,Tang J,Li X,Liu B,Wang W,Zhang D,Guo S

Tue Dec 01 00:00:00 EST 2020

Si-Miao-Yong-An decoction preserves cardiac function and regulates GLC/AMPK/NF-κB and GLC/PPARα/PGC-1α pathways in diabetic mice.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Li L,Chen X,Su C,Wang Q,Li R,Jiao W,Luo H,Tian Y,Tang J,Li X,Liu B,Wang W,Zhang D,Guo S

Tue Dec 01 00:00:00 EST 2020

Tributyltin exposure disturbs hepatic glucose metabolism in male mice.

Toxicology

Xu J,Ou K,Chen C,Li B,Guo J,Zuo Z,Wang C

Sun Sep 01 00:00:00 EDT 2019

Bioinformatics

Protein Aliases: GL-R; Glucagon receptor

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Gene Aliases: GCGR; GGR; GL-R; GR

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UniProt ID: (Human) P47871, (Mouse) Q61606

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Entrez Gene ID: (Human) 2642, (Mouse) 14527

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Function(s)

glucagon receptor activity guanyl-nucleotide exchange factor activity peptide hormone binding signal transducer activity transmembrane signaling receptor activity G-protein coupled receptor activity transmembrane signal receptor

Process(es)

generation of precursor metabolites and energy exocytosis cell surface receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway response to nutrient regulation of blood pressure hormone-mediated signaling pathway glucose homeostasis response to starvation positive regulation of GTPase activity regulation of glycogen metabolic process cellular response to glucagon stimulus signal transduction G-protein coupled receptor signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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GCGR Polyclonal Antibody

GCGR Antibody (26784-1-AP) in IHC (P)

Product Details

26784-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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