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GDF6 Antibody (PA5-78681) in IHC (P)
GDF6 Polyclonal Antibody detects GDF6 protein at cytoplasm in rat brain by immunohistochemical analysis. Sample: Paraffin-embedded rat brain. GDF6 Polyclonal Antibody (Product # PA5-78681) diluted at 1:500. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min.
Product Details
PA5-78681
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human GDF6. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.76 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2735828
Product Specific Information
Positive Control: U87-MG
Predicted Reactivity: Mouse (91%), Bovine (95%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
GDF6 is a growth differentiation factor (GDFs), which are members of the transforming growth factor (TGF) superfamily that is involved in embryonic development and adult tissue homeostasis. Both GDF6 and GDF7 are closely related to GDF5 which has been shown to induce activation of plasminogen activator, thereby inducing angiogenesis. It is predominantly expressed in long bones during fetal embryonic development and is involved in bone formation. In Xenopus, GDF6 is expressed at the edge of the neural plate and within the anterior neural plate including the eye fields. GDF6 is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. It may regulate patterning of the ectoderm by interacting with bone morphogenetic proteins (BMPs), and control eye development. Mutations in this gene result in colobomata, which are congenital abnormalities in ocular development, and in Klippel-Feil syndrome (KFS), a congenital disorder of spinal segmentation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BMP-13; Bone morphogenetic protein 13; GDF-6; growth differentiation factor 16; Growth/differentiation factor 16; Growth/differentiation factor 6; Klip-Feil malformation; Klippel-Feil malformation; Klippel-Feil syndrome
Gene Aliases: BMP-13; BMP13; CDMP2; GDF16; GDF6; KFM; KFS; KFS1; KFSL; LCA17; MCOP4; MCOPCB6; SCDO4; SGM1
UniProt ID: (Human) Q6KF10, (Rat) Q6HA10
Entrez Gene ID: (Human) 392255, (Rat) 252834
apoptotic process
positive regulation of pathway-restricted SMAD protein phosphorylation
BMP signaling pathway
positive regulation of chondrocyte differentiation
activin receptor signaling pathway
growth
regulation of apoptotic process
regulation of MAPK cascade
fat cell differentiation
positive regulation of neuron differentiation
positive regulation of transcription, DNA-templated
cell development
pathway-restricted SMAD protein phosphorylation
SMAD protein signal transduction
positive regulation of p38MAPK cascade
retinal cell apoptotic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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