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Alomone Labs, LTD
Ghrelin Receptor (GHSR) (extracellular) Polyclonal Antibody
FIGURE: 1 / 4
Ghrelin Receptor (GHSR) (extracellular) Antibody (AGR-031-200UL) in ICC/IF
Expression of Ghrelin receptor in human SH-SY5Y cell line - Cell surface detection of Ghrelin receptor in intact living human neuroblastoma (SH-SY5Y) cells. A. Extracellular staining of cells with Anti-Ghrelin Receptor (GHSR) (extracellular) Antibody (#AGR-031), (red), (1:50) followed by goat Anti-rabbit-AlexaFluor-594 secondary Antibody . B. DAPI is used as the counterstain (blue) merged with Anti-Ghrelin ... View More
Product Details
AGR-031-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CRATEFAVRSG, corresponding to amino acid residues 197-207 of rat Ghrelin receptor, 2nd extracellular loop
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
Growth hormone secretagogue receptor 1a (GHSR) is a member of the G-protein coupled receptor family. GHSR may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutionary conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin; however, it may function to attenuate activity of isoform 1a. Mutations to the gene can cause isolated partial growth hormone deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: G-protein coupled receptor; GH-releasing peptide receptor; Ghrelin receptor; GHRP; Ghrp receptor; GHS receptor; GHS-R; Growth hormone secretagogue receptor type 1
Gene Aliases: C530020I22Rik; GHDP; GHSR
UniProt ID: (Human) Q92847, (Mouse) Q99P50, (Rat) O08725
Entrez Gene ID: (Human) 2693, (Mouse) 208188, (Rat) 84022
G-protein coupled receptor signaling pathway
actin polymerization or depolymerization
adult feeding behavior
response to hormone
hormone-mediated signaling pathway
growth hormone secretion
response to food
positive regulation of appetite
negative regulation of interleukin-1 beta production
cellular response to insulin stimulus
positive regulation of multicellular organism growth
negative regulation of tumor necrosis factor biosynthetic process
regulation of hindgut contraction
positive regulation of insulin-like growth factor receptor signaling pathway
negative regulation of interleukin-6 biosynthetic process
positive regulation of fatty acid metabolic process
negative regulation of insulin secretion
decidualization
negative regulation of inflammatory response
regulation of synapse assembly
signal transduction
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