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Invitrogen
Glucagon Receptor Polyclonal Antibody
Product Details
PA5-50668
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to a region derived from internal residues of human glucagon receptor
Conjugate
Form
Liquid
Concentration
2.7 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2636120
Product Specific Information
The antibody detects endogenous levels of total GCGR / Glucagon Receptor protein.
Target Information
Glucagon receptors are G-protein coupled receptors for glucagon and play a central role in the regulation of blood glucose levels and glucose homeostatsis. It regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Glucagon receptors also play an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G-proteins) and modulates the activity of down-stream effectors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: GL-R; Glucagon receptor; glucagon receptor perhaps same as Niddm3
Gene Aliases: GCGR; GGR; GL-R; GR
UniProt ID: (Human) P47871, (Mouse) Q61606, (Rat) P30082
Entrez Gene ID: (Human) 2642, (Mouse) 14527, (Rat) 24953
generation of precursor metabolites and energy
exocytosis
cell surface receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
response to nutrient
regulation of blood pressure
hormone-mediated signaling pathway
glucose homeostasis
response to starvation
positive regulation of GTPase activity
regulation of glycogen metabolic process
cellular response to glucagon stimulus
signal transduction
G-protein coupled receptor signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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