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Invitrogen
Glucagon Receptor Recombinant Rabbit Monoclonal Antibody (21H1L9)
FIGURE: 1 / 2
Glucagon Receptor Antibody (702602) in ICC/IF
For immunofluorescence analysis, U87-MG cells were fixed and permeabilized for detection of endogenous Glucagon Receptor/GCGR using Anti- Glucagon Receptor/GCGR Recombinant Rabbit Monoclonal Antibody (Product # 702602, 5 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that w... View More
Product Details
702602
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Monoclonal
Type
Antibody
Clone
21H1L9
Immunogen
Peptide corresponding to human Glucagon Receptor (aa198-aa211)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2716883
Product Specific Information
This antibody is predicted to react with Monkey, Horse, Bovine, Dog
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
Glucagon receptors are G-protein coupled receptors for glucagon and play a central role in the regulation of blood glucose levels and glucose homeostatsis. It regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Glucagon receptors also play an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G-proteins) and modulates the activity of down-stream effectors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GL-R; Glucagon receptor; glucagon receptor perhaps same as Niddm3
Gene Aliases: GCGR; GGR; GL-R
UniProt ID: (Human) P47871, (Rat) P30082
Entrez Gene ID: (Human) 2642, (Rat) 24953
generation of precursor metabolites and energy
exocytosis
cell surface receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
response to nutrient
regulation of blood pressure
hormone-mediated signaling pathway
glucose homeostasis
response to starvation
positive regulation of GTPase activity
regulation of glycogen metabolic process
cellular response to glucagon stimulus
G-protein coupled receptor signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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