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HAT1 Polyclonal Antibody

HAT1 Antibody in Immunocytochemistry (ICC/IF)

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HAT1 Antibody (11432-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using HAT1 antibody 11432-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

HAT1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

HAT1 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

HAT1 Antibody in Immunoprecipitation (IP)

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Product Details

11432-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:50

Immunocytochemistry (ICC/IF)

1:10-1:100

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

HAT1 Fusion Protein Ag1952 (241-419 aa encoded by BC018682)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MLILTPFQG QGHGAQLLET VHRYYTEFPT VLDITAEDPS KSYVKLRDFV LVKLCQDLPC FSREKLMQGF NEDMAIEAQQ KFKINKQHAR RVYEILRLLV TDMSDAEQYR SYRLDIKRRL ISPYKKKQRD LAKMRKCLRP EELTNQMNQI EISMQHEQLE ESFQELVEDY RRVIERLAQE (241-419 aa encoded by BC018682)

Target Information

The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

A druggable copper-signalling pathway that drives inflammation.

Nature

Solier S,Müller S,Cañeque T,Versini A,Mansart A,Sindikubwabo F,Baron L,Emam L,Gestraud P,Pantoș GD,Gandon V,Gaillet C,Wu TD,Dingli F,Loew D,Baulande S,Durand S,Sencio V,Robil C,Trottein F,Péricat D,Näser E,Cougoule C,Meunier E,Bègue AL,Salmon H,Manel N,Puisieux A,Watson S,Dawson MA,Servant N,Kroemer G,Annane D,Rodriguez R

Mon May 01 00:00:00 EDT 2023

Predisposition to cortical neurodegenerative changes in brains of hypertension prone rats.

Journal of translational medicine

Ben-Shabat M,Awad-Igbaria Y,Sela S,Gross B,Yagil Y,Yagil C,Palzur E

Fri Jan 27 00:00:00 EST 2023

New Cortical Neurodegenerative Pathways in the Hypertensive Rat Brain.

Cerebral cortex (New York, N.Y. : 1991)

Moti BS,Oz E,Olga A,Bella G,Shifra S,Eilam P

Fri Oct 22 00:00:00 EDT 2021

Histone acetyltransferase 1 is a succinyltransferase for histones and non-histones and promotes tumorigenesis.

EMBO reports

Yang G,Yuan Y,Yuan H,Wang J,Yun H,Geng Y,Zhao M,Li L,Weng Y,Liu Z,Feng J,Bu Y,Liu L,Wang B,Zhang X

Wed Feb 03 00:00:00 EST 2021

Hepatic COX-2 expression protects mice from an alcohol-high fat diet-induced metabolic disorder by involving protein acetylation related energy metabolism.

Alcohol (Fayetteville, N.Y.)

Chen M,Sun X,Wei W,Cucarella C,Martín-Sanz P,Casado M,Pi L,Ren B,Cao Q

Sat May 01 00:00:00 EDT 2021

Histone acetyltransferase 1 promotes gemcitabine resistance by regulating the PVT1/EZH2 complex in pancreatic cancer.

Cell death & disease

Sun Y,Ren D,Zhou Y,Shen J,Wu H,Jin X

Sat Sep 25 00:00:00 EDT 2021

Identification and characterization of an endoplasmic reticulum localization motif.

Biochemical and biophysical research communications

Nie YW,Wang M,Zhang P,Huan L,Liu DJ

Fri Apr 22 00:00:00 EDT 2016

Identification and characterization of an endoplasmic reticulum localization motif.

Biochemical and biophysical research communications

Nie YW,Wang M,Zhang P,Huan L,Liu DJ

Fri Apr 22 00:00:00 EDT 2016

Acetylproteomic analysis reveals functional implications of lysine acetylation in human spermatozoa (sperm).

Molecular & cellular proteomics : MCP

Yu H,Diao H,Wang C,Lin Y,Yu F,Lu H,Xu W,Li Z,Shi H,Zhao S,Zhou Y,Zhang Y

Wed Apr 01 00:00:00 EDT 2015

Acetylproteomic analysis reveals functional implications of lysine acetylation in human spermatozoa (sperm).

Molecular & cellular proteomics : MCP

Yu H,Diao H,Wang C,Lin Y,Yu F,Lu H,Xu W,Li Z,Shi H,Zhao S,Zhou Y,Zhang Y

Wed Apr 01 00:00:00 EDT 2015

Bioinformatics

Protein Aliases: histidine aminotransferase 1; Histone acetyltransferase 1; Histone acetyltransferase type B catalytic subunit

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Gene Aliases: 2410071B14Rik; AA536933; Hat-1; HAT1; KAT1

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UniProt ID: (Human) O14929, (Mouse) Q8BY71

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Entrez Gene ID: (Human) 8520, (Mouse) 107435

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Function(s)

histone acetyltransferase activity protein binding H4 histone acetyltransferase activity histone binding transferase activity transferase activity, transferring acyl groups histone modifying enzyme

Process(es)

DNA packaging DNA replication-dependent nucleosome assembly DNA replication-independent nucleosome assembly chromatin silencing at telomere internal protein amino acid acetylation response to nutrient chromatin modification histone H4 acetylation histone acetylation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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HAT1 Polyclonal Antibody

HAT1 Antibody (11432-1-AP) in ICC/IF

Product Details

11432-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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