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Product Details
MA5-15769
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
8F9G7
Immunogen
A 15 amino acid peptide near the amino terminus of human Hax1a.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11157011
Target Information
The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ17042; FLJ18492; FLJ93803; HAX-1; HCLS1 (and PKD2) associated protein; HCLS1-associated protein X-1; HS1 binding protein; HS1-associated protein X-1; HS1-associating protein X-1; HS1-binding protein 1; HSP1BP-1; OTTHUMP00000034190; RP11-137P24.1
Gene Aliases: HAX-1; HAX1; HCLSBP1; HS1BP1; HSP1BP-1; mHAX-1s; SCN3; SIG-111; Silg111
UniProt ID: (Human) O00165, (Rat) Q7TSE9, (Mouse) O35387
Entrez Gene ID: (Human) 10456, (Rat) 291202, (Mouse) 23897
positive regulation of phosphatidylinositol 3-kinase signaling
regulation of actin filament polymerization
positive regulation of granulocyte differentiation
positive regulation of peptidyl-serine phosphorylation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of protein kinase B signaling
cellular response to cytokine stimulus
positive regulation of actin cytoskeleton reorganization
mitochondrion organization
regulation of apoptotic process
negative regulation of apoptotic process
regulation of mitophagy
regulation of protein targeting to mitochondrion
cell surface receptor signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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