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HFE2 Antibody (MA5-43773) in IHC (P)
Immunohistochemistry of HFE2 in paraffin-embedded human liver tissue. Samples were incubated in monoclonal HFE2 antibody (Product # MA5-43773) using a dilution of 30 µg/mL, followed by HRP-Linked Caprine Anti-Mouse IgG at a dilution of 2 µg/mL and DAB.
Product Details
MA5-43773
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
C5
Immunogen
Lys234-Ser416 (Accession Q6ZVN8), with N-terminal His Tag
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A/G
Storage buffer
PBS with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2912705
Target Information
HFE2 is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DL M; haemojuvelin; HEMOCHROMATOSIS; hemochromatosis type 2 (juvenile) (human homolog); Hemochromatosis type 2 protein; hemochromatosis type 2 protein homolog; Hemojuvelin; Hemojuvelin BMP coreceptor; HFE 2; MGC23953; OTTHUMP00000059680; repulsive guidance molecule c; RGM C; RGM domain family member C
Gene Aliases: HFE2; HFE2A; HJV; JH; RGMC
UniProt ID: (Human) Q6ZVN8
Entrez Gene ID: (Human) 148738, (Rat) 310681
biological_process
BMP signaling pathway
negative regulation of BMP signaling pathway
positive regulation of transcription from RNA polymerase II promoter
iron ion homeostasis
negative regulation of transcription from RNA polymerase II promoter
cellular iron ion homeostasis
protein autoprocessing
activin receptor signaling pathway
cellular response to BMP stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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