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Product Details
PA5-60760
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human HINT1. Recombinant protein control fragment (Product #RP-96928).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2642437
Product Specific Information
Immunogen sequence: IPKKHISQIS VAEDDDESLL GHLMIVGKKC AADLGLNKGY RMVVNEGSDG GQSVYHVHLH VL
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 92%.
Target Information
Histidine triad nucleotide-binding protein 1 (HINT1) is a member of the histidine triad (HIT) protein family, a group of small nucleotide-binding and -hydrolyzing proteins. HINT1 interacts with several diverse proteins and has been suggested to have tumor suppressive activities. HINT1 catalyzes the hydrolysis of adenosine 5'-monophoramidate substrates such as AMP-morpholidate, but its enzymatic function does not appear to play a role in its tumor suppression. Recent experiments demonstrate that HINT1 forms a complex with POSH and JNK in vivo, inhibiting AP-1 activity and the phosphorylation of c-Jun, and this action could contribute to the tumor suppressor activity of HINT1. Other studies raise the possibility of HINT1 as a candidate gene for schizophrenia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 17 kDa inhibitor of protein kinase C; adenosine 5'-monophosphoramidase; Adenosine 5'-monophosphoramidase HINT1; Desumoylating isopeptidase HINT1; FLJ30414; FLJ32340; Histidine triad nucleotide-binding protein 1; PKC inhibitor/ interacting protein; PKCI-1; Protein kinase C inhibitor 1; protein kinase C, iota; Protein kinase C-interacting protein 1
Gene Aliases: AA673479; HINT; HINT1; Ipk1; NMAN; Pkci; PKCI-1; PKCI1; Prkci; PRKCNH1
UniProt ID: (Human) P49773, (Mouse) P70349, (Rat) P62959
Entrez Gene ID: (Human) 3094, (Mouse) 15254, (Rat) 690660
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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