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Product Details
25107-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HIPK3 Fusion Protein Ag18897
Conjugate
Form
Liquid
Concentration
300 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
HIPK3 is a serine/threonine kinase involved in signal transduction, cellular communication, and multidrug resistance of tumors and plays a role in the phosphorylation of FADD. HIPK3 negatively regulates apoptosis by promoting FADD phosphorylation. This kinase enhances androgen receptor-mediated transcription, and may act as a transcriptional corepressor for NK homeodomain transcription factors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Androgen receptor-interacting nuclear protein kinase; ANPK; Fas-interacting serine/threonine-protein kinase; FIST; HCMV-interacting protein; Homeodomain-interacting protein kinase 3; Homolog of protein kinase YAK1; Nbak3; Nuclear body-associated kinase 3; nuclear serine/threonine protein kinase; RP1-8L15.1
Gene Aliases: ANPK; DYRK6; Fist; FIST3; HIPK3; mir-1902; PKY; YAK1
UniProt ID: (Human) Q9H422, (Mouse) Q9ERH7, (Rat) O88850
Entrez Gene ID: (Human) 10114, (Mouse) 15259, (Rat) 83617
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
protein phosphorylation
apoptotic process
mRNA transcription
phosphorylation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
negative regulation of apoptotic process
positive regulation of DNA binding
negative regulation of JUN kinase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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