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Product Details
PA5-113271
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Minor histocompatibility antigen H13 protein (336-377AA)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Wet ice
RRID
AB_2868005
Target Information
Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May play a role in graft rejection. May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1. Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139- dependent manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hIMP1; histocompatibility (minor) 13; histocompatibility 13; IMP-1; Intramembrane protease 1; minor histocompatibility antigen 13; Minor histocompatibility antigen H13; presenilin-like aspartyl protease; Presenilin-like protein 3; Signal peptide peptidase; signal peptide peptidase beta; signal peptide peptidase like 1
Gene Aliases: 1200006O09Rik; 4930443L17Rik; 5031424B04Rik; AV020344; H-13; H13; HM13; IMP1; IMPAS; IMPAS-1; MSTP086; PSENL3; PSL3; SPP; SPPL1
UniProt ID: (Mouse) Q9D8V0, (Human) Q9H111
Entrez Gene ID: (Mouse) 14950, (Human) 81502
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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