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HOXA10 Antibody (PA5-121209) in WB
Western blot analysis of HOXA10 in extracts of various cell lines. Samples were incubated with HOXA10 Polyclonal antibody (Product # PA5-121209) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
Product Details
PA5-121209
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 236-336 of human HOXA10 (NP_061824.3).
Conjugate
Form
Liquid
Concentration
2.38 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2914781
Product Specific Information
Positive test controls include: SKOV3, HT-29, Rat kidney, Mouse kidney. The target is usually found in the following locations: Nucleus.
Immunogen sequence: LGAGPFPAQP PGRGFDLPPA LASGSADAAR KERALDSPPP PTLACGSGGG SQGDEEAHAS SSAAEELSPA PSESSKASPE KDSLGNSKGE NAANWLTAKS G
Target Information
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factorm HOXA10, that may regulate gene expression, morphogenesis, and differentiation. More specifically, HOXA10 may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the downstream homeobox A9 gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: homeo box A10; homeobox A10; homeobox protein 1H; Homeobox protein Hox-1.8; Homeobox protein Hox-1H; Homeobox protein Hox-A10; homeobox protein HOXA10; Hox-18; PL
Gene Aliases: Hox-1.8; HOX1; HOX1.8; HOX1H; Hoxa-10; HOXA10; PL
UniProt ID: (Human) P31260, (Mouse) P31310
Entrez Gene ID: (Human) 3206, (Rat) 103692129, (Mouse) 15395
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
protein binding
histone deacetylase binding
DNA binding
sequence-specific DNA binding
helix-turn-helix transcription factor
homeodomain transcription factor
DNA-binding transcription factor
gene-specific transcriptional regulator
skeletal system development
transcription from RNA polymerase II promoter
multicellular organism development
spermatogenesis
single fertilization
male gonad development
anterior/posterior pattern specification
proximal/distal pattern formation
embryonic limb morphogenesis
positive regulation of transcription from RNA polymerase II promoter
uterus development
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of gene expression
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