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Invitrogen
Histone Macro-H2A.1 Recombinant Rabbit Monoclonal Antibody (ARC1396)
Product Details
MA5-35752
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
ARC1396
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human macroH2A1 (O75367)
Conjugate
Form
Liquid
Concentration
0.95 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2849652
Product Specific Information
Immunogen sequence: IHSEISNLAG FEVEAIINPT NADIDLKDDL GNTLEKKGGK EFVEAVLELR KKNGPLEVAG AAVSAGHGLP AKFVIHCNSP VWGADKCEEL LEKTVKNCLA L
Target Information
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Core histone macro-H2A.1; H2A histone family, member Y; H2A.y; H2A/y; Histone H2A.y; Histone macroH2A1; histone macroH2A1.1; histone macroH2A1.2; MACROH2A1.2; Medulloblastoma antigen MU-MB-50.205; mH2A1
Gene Aliases: H2A.y; H2A/y; H2AF12M; H2AFY; MACROH2A1; MACROH2A1.1; macroH2A1.2; mH2A1
UniProt ID: (Human) O75367, (Rat) Q02874, (Mouse) Q9QZQ8
Entrez Gene ID: (Human) 9555, (Rat) 29384, (Mouse) 26914
rDNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
core promoter sequence-specific DNA binding
DNA binding
protein binding
double-stranded methylated DNA binding
enzyme binding
protein kinase binding
protein serine/threonine kinase inhibitor activity
chromatin DNA binding
nucleosomal DNA binding
transcription regulatory region DNA binding
protein heterodimerization activity
molecular_function
chromatin binding
histone
negative regulation of transcription from RNA polymerase II promoter
regulation of cell growth
nucleosome assembly
chromatin silencing
dosage compensation
covalent chromatin modification
regulation of lipid metabolic process
negative regulation of histone phosphorylation
positive regulation of maintenance of mitotic sister chromatid cohesion
regulation of gene expression, epigenetic
positive regulation of keratinocyte differentiation
negative regulation of gene expression, epigenetic
positive regulation of gene expression, epigenetic
negative regulation of histone H3-K4 methylation
negative regulation of histone H3-K27 methylation
regulation of chromatin silencing at rDNA
establishment of protein localization to chromatin
negative regulation of protein serine/threonine kinase activity
negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
negative regulation of cell cycle G2/M phase transition
negative regulation of protein localization to chromosome, telomeric region
biological_process
chromatin modification
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