Proteintech

HuR Monoclonal Antibody (1A11H2)

HuR Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 6

HuR Antibody (66549-1-IG) in ICC/IF

Immunofluorescent analysis of ( 4% PFA) fixed HepG2 cells using 66549-1-IG (HuR antibody) at dilution of 1:100 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

HuR Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Image Gallery

Product Details

66549-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:5,000-1:50,000

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:500-1:2,000

Immunocytochemistry (ICC/IF)

1:50-1:500

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Not Applicable

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

1A11H2

Immunogen

HuR Fusion Protein Ag2249 (1-326 aa encoded by BC003376)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSNGYEDHM AEDCRGDIGR TNLIVNYLPQ NMTQDELRSL FSSIGEVESA KLIRDKVAGH SLGYGFVNYV TAKDAERAIN TLNGLRLQSK TIKVSYARPS SEVIKDANLY ISGLPRTMTQ KDVEDMFSRF GRIINSRVLV DQTTGLSRGV AFIRFDKRSE AEEAITSFNG HKPPGSSEPI TVKFAANPNQ NKNVALLSQL YHSPARRFGG PVHHQAQRFR FSPMGVDHMS GLSGVNVPGN ASSGWCIFIY NLGQDADEGI LWQMFGPFGA VTNVKVIRDF NTNKCKGFGF VTMTNYEEAA MAIASLNGYR LGDKILQVSF KTNKSHK (1-326 aa encoded by BC003376)

Target Information

The protein encoded by this gene is a member of the ELAVL protein family. This encoded protein contains 3 RNA-binding domains and binds cis-acting AU-rich elements. It destabilizes mRNAs and thereby regulates gene expression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Stress granules affect the sensitivity of renal cancer cells to sorafenib by sequestering and stabilizing COX‑2 mRNA.

Oncology letters

Dai H,Wang G,Cao W,Qi W,Chen W,Guo H

Thu Jun 01 00:00:00 EDT 2023

LncGMDS-AS1 promotes the tumorigenesis of colorectal cancer through HuR-STAT3/Wnt axis.

Cell death & disease

Ye D,Liu H,Zhao G,Chen A,Jiang Y,Hu Y,Liu D,Xie N,Liang W,Chen X,Zhang H,Li C,Wang J,Sun D,Chen W,Tan D,Wang Q,Wang H,Yu D,Wu B,Wang M,Cui S,Liu S,Zhang X

Mon Feb 27 00:00:00 EST 2023

Long non-coding RNA DEPDC1-AS1 promotes proliferation and migration of human gastric cancer cells HGC-27 via the human antigen R-F11R pathway.

The Journal of international medical research

Xu W,Wang J,Xu J,Li S,Zhang R,Shen C,Xie M,Zheng B,Gu M

Fri Apr 01 00:00:00 EDT 2022

ELAV-like RNA binding protein 1 regulates osteogenesis in diabetic osteoporosis: Involvement of divalent metal transporter 1.

Molecular and cellular endocrinology

Ren Y,Yang M,Wang X,Xu B,Xu Z,Su B

Fri Apr 15 00:00:00 EDT 2022

ELAV-like RNA binding protein 1 regulates osteogenesis in diabetic osteoporosis: Involvement of divalent metal transporter 1.

Molecular and cellular endocrinology

Ren Y,Yang M,Wang X,Xu B,Xu Z,Su B

Fri Apr 15 00:00:00 EDT 2022

Butyrate mediated regulation of RNA binding proteins in the post-transcriptional regulation of inflammatory gene expression.

Cellular signalling

Torun A,Enayat S,Sheraj I,Tunçer S,Ülgen DH,Banerjee S

Sun Dec 01 00:00:00 EST 2019

Bioinformatics

Protein Aliases: ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); ELAV like 1; Elav-like generic protein; ELAV-like protein 1; embryonic lethal, abnormal vision, drosophila, homolog-like 1; Hu antigen R; HU-antigen A; Hu-antigen R; Human antigen R; HuR; MelG

View more View less

Gene Aliases: 2410055N02Rik; ELAV1; ELAVL1; Elra; Hua; HUR; MelG; W91709

View more View less

UniProt ID: (Human) Q15717, (Mouse) P70372, (Rat) B5DF91

View more View less

Entrez Gene ID: (Human) 1994, (Mouse) 15568, (Rat) 363854

View more View less

Function(s)

nucleotide binding RNA binding double-stranded RNA binding mRNA binding mRNA 3'-UTR binding protein binding AU-rich element binding protein kinase binding mRNA 3'-UTR AU-rich region binding protein homodimerization activity poly(A) RNA binding nucleic acid binding translation initiation factor

Process(es)

mRNA splicing, via spliceosome multicellular organism development regulation of mRNA stability positive regulation of translation mRNA stabilization negative regulation of gene silencing by miRNA 3'-UTR-mediated mRNA stabilization regulation of stem cell population maintenance regulation of translation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

HuR Monoclonal Antibody (1A11H2)

HuR Antibody (66549-1-IG) in ICC/IF

Product Details

66549-1-IG

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!