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Product Details
PA5-115413
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human IL2RG(Accession P31785), corresponding to amino acid residues S53-S103.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2900049
Product Specific Information
Antibody detects endogenous levels of total IL2RG.
Target Information
IL2RG is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD132; CD132 antigen; common cytokine receptor gamma chain; Cytokine receptor common subunit gamma; gammaC; IL-2 receptor subunit gamma; IL-2R subunit gamma; IL2R gamma; interleukin 2 receptor, gamma; interleukin 2 receptor, gamma (severe combined immunodeficiency); Interleukin-2 receptor subunit gamma; p64
Gene Aliases: [g]c; Ab2-183; CD132; CIDX; gamma(c); gc; IL-2RG; IL2RG; IMD4; P64; SCIDX; SCIDX1
UniProt ID: (Human) P31785, (Mouse) P34902
Entrez Gene ID: (Human) 3561, (Rat) 140924, (Mouse) 16186
MAPK cascade
immune response
signal transduction
viral process
interleukin-4-mediated signaling pathway
interleukin-2-mediated signaling pathway
interleukin-7-mediated signaling pathway
positive regulation of GTPase activity
regulation of gene expression
positive regulation of gene expression
cytokine-mediated signaling pathway
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
positive regulation of T cell differentiation in thymus
positive regulation of B cell differentiation
positive regulation of lymphocyte differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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