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Product Details
BS-0173R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human IRS-2, amino acids 501-600.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 4PS; Insulin receptor substrate 2; IRS-2; tyrosine kinase substrate
Gene Aliases: 4PS; IRS-2; IRS2
UniProt ID: (Human) Q9Y4H2, (Mouse) P81122
Entrez Gene ID: (Human) 8660, (Rat) 29376, (Mouse) 384783
signal transducer activity
Ras guanyl-nucleotide exchange factor activity
insulin receptor binding
protein binding
1-phosphatidylinositol-3-kinase activity
protein kinase binding
protein phosphatase binding
protein domain specific binding
phosphatidylinositol 3-kinase binding
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
14-3-3 protein binding
positive regulation of mesenchymal cell proliferation
negative regulation of B cell apoptotic process
brain development
cell proliferation
positive regulation of cell proliferation
insulin receptor signaling pathway
response to glucose
negative regulation of plasma membrane long-chain fatty acid transport
positive regulation of glucose metabolic process
regulation of lipid metabolic process
positive regulation of cell migration
mammary gland development
positive regulation of B cell proliferation
positive regulation of fatty acid beta-oxidation
positive regulation of insulin secretion
cellular response to insulin stimulus
negative regulation of kinase activity
positive regulation of glycogen biosynthetic process
positive regulation of glucose import
cellular response to glucose stimulus
cellular response to peptide
signal transduction
MAPK cascade
glucose metabolic process
regulation of phosphatidylinositol 3-kinase signaling
phosphatidylinositol-3-phosphate biosynthetic process
positive regulation of GTPase activity
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
lipid homeostasis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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