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Product Details
MA1-35525
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Pig,
Rabbit
Published species
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2D11-H5
Immunogen
Purified pig insulin, conjugated to KLH
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
purified
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
4° C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_1076193
Product Specific Information
Insulin is a protein consisting of an α-chain of 21 amino acids and a β-chain of 30 amino acids and produced in the β-cells of the pancreas. 2D11-H5 is a specific insulin antibody as tested by ELISA and on human pancreatic tissue.
Target Information
Insulin is a peptide hormone secreted by beta cells of the pancreatic islets. It regulates carbohydrate, protein and lipid metabolism by enhancing membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Insulin is 51-amino acid polypeptide product produced from a precursor peptide, proinsulin. Proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds and one molecule of C-peptide. Insulin deficiency results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of b-cell origin such as insulinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Ins; Insulin; Insulin-1; Insulin-2; preproinsulin; proinsulin
Gene Aliases: AA986540; IDDM; IDDM1; IDDM2; ILPR; INS; Ins-1; Ins-2; Ins1; Ins2; Ins2-rs1; InsII; IRDN; Mody; MODY10; Mody4; proinsulin
UniProt ID: (Pig) P01315, (Human) P01308, (Mouse) P01325, (Mouse) P01326
Entrez Gene ID: (Pig) 397415, (Bovine) 280829, (Rabbit) 100009181, (Human) 3630, (Mouse) 16333, (Mouse) 16334
negative regulation of acute inflammatory response
glucose metabolic process
regulation of cellular amino acid metabolic process
acute-phase response
G-protein coupled receptor signaling pathway
positive regulation of cell proliferation
insulin receptor signaling pathway
lipid biosynthetic process
glycoprotein biosynthetic process
positive regulation of nitric oxide mediated signal transduction
positive regulation of glucose metabolic process
positive regulation of phosphatidylinositol 3-kinase signaling
lactate biosynthetic process
regulation of transmembrane transporter activity
positive regulation of cell migration
positive regulation of protein autophosphorylation
activation of protein kinase B activity
negative regulation of NAD(P)H oxidase activity
wound healing
lipoprotein biosynthetic process
negative regulation of protein catabolic process
glucose homeostasis
positive regulation of MAPK cascade
negative regulation of gluconeogenesis
positive regulation of fatty acid biosynthetic process
positive regulation of glycogen biosynthetic process
positive regulation of DNA replication
negative regulation of glycogen catabolic process
positive regulation of glycolytic process
positive regulation of mitotic nuclear division
negative regulation of proteolysis
negative regulation of fatty acid metabolic process
positive regulation of glucose import
positive regulation of insulin receptor signaling pathway
alpha-beta T cell activation
negative regulation of protein secretion
positive regulation of cytokine secretion
positive regulation of peptidyl-tyrosine phosphorylation
negative regulation of lipid catabolic process
positive regulation of lipoprotein lipase activity
positive regulation of NF-kappaB transcription factor activity
positive regulation of protein kinase B signaling
fatty acid homeostasis
negative regulation of respiratory burst involved in inflammatory response
positive regulation of respiratory burst
positive regulation of protein localization to nucleus
positive regulation of dendritic spine maintenance
regulation of protein localization to plasma membrane
negative regulation of reactive oxygen species biosynthetic process
response to L-arginine
neuron projection maintenance
negative regulation of feeding behavior
signal transduction
feeding behavior
protein secretion
response to heat
response to glucose
positive regulation of gene expression
response to nutrient levels
positive regulation of insulin secretion
response to food
negative regulation of appetite
positive regulation of mammary gland epithelial cell proliferation
positive regulation of Rho protein signal transduction
estradiol secretion
negative regulation of apoptotic process
glucose import in response to insulin stimulus
positive regulation of protein secretion
response to growth hormone
positive regulation of peptide hormone secretion
positive regulation of cell maturation
negative regulation of lactation
positive regulation of lactation
positive regulation of blood circulation
response to butyrate
MAPK cascade
regulation of transcription, DNA-templated
ER to Golgi vesicle-mediated transport
cell-cell signaling
glucose transport
positive regulation of cell growth
positive regulation of cellular protein metabolic process
negative regulation of protein oligomerization
regulation of protein localization
cellular protein metabolic process
positive regulation of nitric oxide biosynthetic process
positive regulation of cell differentiation
negative regulation of vasodilation
positive regulation of vasodilation
positive regulation of lipid biosynthetic process
regulation of protein secretion
positive regulation of nitric-oxide synthase activity
positive regulation of brown fat cell differentiation
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
carbohydrate metabolic process
negative regulation of transcription from RNA polymerase II promoter
activation of MAPK activity
ER overload response
activation of JUN kinase activity
myoblast fusion
regulation of gene expression
myotube differentiation
lipid catabolic process
regulation of phosphorylation
regulation of protein binding
positive regulation of phosphatidylinositol 3-kinase activity
canonical Wnt signaling pathway
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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