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JAM3 Antibody (40-8900) in IHC (P)
Immunohistochemistry analysis of JAM-C showing staining in the membrane of paraffin-embedded human kidney tissue (right) compared to a negative control without primary antibody (left). To expose target proteins, antigen retrieval was performed using 10mM sodium citrate (pH 6.0), microwaved for 8-15 min. Following antigen retrieval, tissues were blocked in 3% H2O2-methanol for 15 min at room temperature, was... View More
Product Details
40-8900
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide derived from the C-terminal region of the mouse and rat JAM-C proteins, which differ from human by three amino acid replacements
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2533485
Target Information
JAM3 is involved in tight junctions and represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: JAM-2; JAM-3; JAM-C; junction cell adhesion molecule 3; junction cell adhesion molecule C; Junctional adhesion molecule 3; Junctional adhesion molecule C
Gene Aliases: 1110002N23Rik; JAM-2; JAM-3; JAM-C; JAM3; JAMC; Jcam3; UNQ859/PRO1868
UniProt ID: (Human) Q9BX67, (Mouse) Q9D8B7
Entrez Gene ID: (Human) 83700, (Mouse) 83964
angiogenesis
neutrophil homeostasis
adaptive immune response
myeloid progenitor cell differentiation
leukocyte migration involved in inflammatory response
cell-matrix adhesion
spermatid development
transmission of nerve impulse
establishment of cell polarity
extracellular matrix organization
axon regeneration
myelination
leukocyte migration
regulation of neutrophil chemotaxis
regulation of actin cytoskeleton organization by cell-cell adhesion
cell adhesion
spermatogenesis
cell migration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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