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FIGURE: 1 / 1
JARID2 Antibody (PA5-97257) in WB
Western blot analysis of JARID2 in extracts of various cell lines. Samples were incubated with JARID2 Polyclonal antibody (Product # PA5-97257) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
Product Details
PA5-97257
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1027-1246 of human JARID2 (NP_0049642)
Conjugate
Form
Liquid
Concentration
0.56 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2809059
Product Specific Information
Immunogen sequence: ETVHFATTQW TSMGFETAKE MKRRHIAKPF SMEKLLYQIA QAEAKKENGP TLSTISALLD ELRDTELRQR RQLFEAGLHS SARYGSHDGS STVADGKKKP RKWLQLETSE RRCQICQHLC YLSMVVQENE NVVFCLECAL RHVEKQKSCR GLKLMYRYDE EQIISLVNQI CGKVSGKNGS IENCLSKPTP KRGPRKRATV DVPPSRLSAS SSSKSASSSS; Positive Samples: HL-60, Mouse thymus, Rat heart; Cellular Location: Nucleus
Target Information
Jumonji (JARID2) is a nuclear protein that participates in the negative regulation of cell growth. It is required for neural tube formation and is essential for normal heart development and function. Also, it is a part of a group of proteins characterized by a novel structural motif, the JmjC domain, which is implicated in chromatin regulation through histone demethylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: JARD2 antibody; jumonji homolog; jumonji, AT rich interactive domain 2; jumonji-like protein; Jumonji/ARID domain-containing protein 2; Protein Jumonji
Gene Aliases: JARID2; JMJ; jumonji
UniProt ID: (Human) Q92833, (Mouse) Q62315
Entrez Gene ID: (Human) 3720, (Mouse) 16468, (Rat) 681740
negative regulation of transcription from RNA polymerase II promoter
liver development
transcription, DNA-templated
central nervous system development
negative regulation of cell proliferation
covalent chromatin modification
negative regulation of histone methylation
negative regulation of gene expression, epigenetic
negative regulation of transcription, DNA-templated
spleen development
thymus development
stem cell differentiation
positive regulation of histone H3-K9 methylation
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
chromatin modification
cell differentiation
regulation of cell proliferation
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