Invitrogen

JNK1/JNK3 Recombinant Rabbit Monoclonal Antibody (ARC1163)

View all (3) JNK1/JNK3 antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-35628

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

ARC1163

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-383 of human JNK1 (P45983)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.2 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2849528

Product Specific Information

Immunogen sequence: MSRSKRDNNF YSVEIGDSTF TVLKRYQNLK PIGSGAQGIV CAAYDAILER NVAIKKLSRP FQNQTHAKRA YRELVLMKCV NHKNIIGLLN VFTPQKSLEE FQDVYIVMEL MDANLCQVIQ MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTAGTSF MMTPYVVTRY YRAPEVILGM GYKENVDLWS VGCIMGEMVC HKILFPGRDY IDQWNKVIEQ LGTPCPEFMK KLQPTVRTYV ENRPKYAGYS FEKLFPDVLF PADSEHNKLK ASQARDLLSK MLVIDASKRI SVDEALQHPY INVWYDPSEA EAPPPKIPDK QLDEREHTIE EWKELIYKEV MDLEERTKNG VIRGQPSPLG AAV

Target Information

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrome c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: c-Jun N-terminal kinase 1; c-Jun N-terminal kinase 3; JNK-46; JNK1 beta1 protein kinase; JNK3 alpha protein kinase; JNK3 beta1 protein kinase; JNK3 beta2 protein kinase; JUN N-terminal kinase; MAP kinase 10; MAP kinase 8; MAP kinase p49 3F12; MAPK 10; MAPK 8; mitogen activated protein kinase 10; mitogen activated protein kinase 8; Mitogen-activated protein kinase 10; Mitogen-activated protein kinase 8; mitogen-activated protein kinase 8 isoform JNK1 alpha1; mitogen-activated protein kinase 8 isoform JNK1 beta2; p54 gamma; p54-beta; protein kinase mitogen-activated 8; SAPK gamma; SAPK-beta; SAPK/Erk/kinase 2; SAPK1b; SAPK1c; Stress activated protein kinase beta; stress-activated protein kinase 1; Stress-activated protein kinase 1b; Stress-activated protein kinase 1c; Stress-activated protein kinase JNK1; Stress-activated protein kinase JNK3

View more View less

Gene Aliases: AI849689; C230008H04Rik; JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2; JNK3; JNK3A; JNK3B1; JNK3B2; MAPK10; MAPK8; p493F12; p54bSAPK; PRKM10; PRKM8; SAPb; SAPK(beta); SAPK1; SAPK1B; SAPK1C; SAPKC; Serk2

View more View less

UniProt ID: (Human) P53779, (Human) P45983, (Mouse) Q61831, (Rat) P49187, (Rat) P49185, (Mouse) Q91Y86

View more View less

Entrez Gene ID: (Human) 5602, (Human) 5599, (Mouse) 26414, (Rat) 25272, (Rat) 116554, (Mouse) 26419

View more View less

Function(s)
JUN kinase activity MAP kinase kinase activity protein binding ATP binding protein serine/threonine kinase activity kinase activity enzyme binding histone deacetylase regulator activity histone deacetylase binding nucleotide binding protein kinase activity MAP kinase activity transferase activity transferase activity, transferring phosphorus-containing groups non-receptor serine/threonine protein kinase
Process(es)
activation of MAPK activity protein phosphorylation signal transduction JNK cascade JUN phosphorylation response to light stimulus Fc-epsilon receptor signaling pathway regulation of circadian rhythm rhythmic process regulation of sequence-specific DNA binding transcription factor activity response to stress response to UV positive regulation of gene expression regulation of macroautophagy peptidyl-serine phosphorylation peptidyl-threonine phosphorylation regulation of histone deacetylation positive regulation of cyclase activity negative regulation of protein binding regulation of protein localization positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of protein metabolic process cellular response to lipopolysaccharide cellular response to mechanical stimulus positive regulation of deacetylase activity positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway negative regulation of transcription from RNA polymerase II promoter phosphorylation locomotor rhythm MAPK cascade ossification regulation of transcription, DNA-templated inflammatory response response to osmotic stress response to heat regulation of gene expression positive regulation of cell migration positive regulation of microtubule polymerization neuron projection development response to hydrogen peroxide positive regulation of DNA replication response to cadmium ion determination of dorsal identity cellular response to hydrogen peroxide cellular response to nitric oxide type B pancreatic cell apoptotic process neuronal stem cell population maintenance programmed necrotic cell death positive regulation of determination of dorsal identity positive regulation of apoptotic signaling pathway
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support