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Product Details
35-8500
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Chicken,
Human,
Mouse,
Rabbit,
Rat
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
6F
Immunogen
Fusion protein encompassing the N-terminus of mouse Kaiso
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2533226
Target Information
This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-alpha 2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Kaiso; kaiso transcription factor; RP23-322E15.9; Transcriptional regulator Kaiso; WUGSC:H_DJ525N14.1; Zinc finger and BTB domain-containing protein 33; zinc finger transcription factor Kaiso
Gene Aliases: AW260253; E130014G12Rik; KAISO; RGD1566309; ZBTB33; ZNF-kaiso; ZNF348
UniProt ID: (Human) Q86T24, (Mouse) Q8BN78
Entrez Gene ID: (Rabbit) 100348939, (Human) 10009, (Chicken) 422367, (Dog) 100685062, (Rat) 501506, (Mouse) 56805
protein binding
methyl-CpG binding
sequence-specific DNA binding
metal ion binding
molecular_function
nucleic acid binding
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
C2H2 zinc finger transcription factor
transcription, DNA-templated
Wnt signaling pathway
intracellular signal transduction
negative regulation of transcription, DNA-templated
biological_process
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
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